Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation

Genes, Brain, and Behavior
K SchindowskiL Buée

Abstract

The aim of the present study was to investigate the relation between neurogenesis, cell cycle reactivation and neuronal death during tau pathology in a novel tau transgenic mouse line THY-Tau22 with two frontotemporal dementia with parkinsonism linked to chromosome-17 mutations in a human tau isoform. This mouse displays all Alzheimer disease features of neurodegeneration and a broad timely resolution of tau pathology with hyperphosphorylation of tau at younger age (up to 6 months) and abnormal tau phosphorylation and tau aggregation in aged mice (by 10 months). Here, we present a follow-up of cell cycle markers with aging in control and transgenic mice from different ages. We show that there is an increased neurogenesis during tau hyperphosphorylation and cell cycle events during abnormal tau phosphorylation and tau aggregation preceding neuronal death and neurodegeneration. However, besides phosphorylation, other mechanisms including tau mutations and changes in tau expression and/or splicing may be also involved in these mechanisms of cell cycle reactivation. Altogether, these data suggest that cell cycle events in THY-Tau22 are resulting from neurogenesis in young animals and cell death in older ones. It suggests that neuro...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Apr 1, 1991·Current Opinion in Cell Biology·J L Maller
Jul 27, 1995·Nature·J Pines
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Dec 16, 1993·Nature·Y XiongD Beach
Jun 1, 1993·Trends in Biochemical Sciences·J Pines
Jun 18, 1998·Annals of Neurology·P PoorkajG D Schellenberg
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·M G SpillantiniB Ghetti
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·M K AhlijanianJ D McNeish
Sep 1, 2000·Brain Research. Brain Research Reviews·L BuéeP R Hof
Oct 3, 2000·The Journal of Biological Chemistry·J GötzR M Nitsch
Dec 22, 2000·Neurobiology of Aging·J W HussemanI Vincent
Jun 15, 2001·The Journal of Comparative Neurology·H A Cameron, R D McKay
Sep 25, 2002·Neuroscience Letters·W P GrayL E Sundström
Oct 25, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Agata CopaniFerdinando Nicoletti
Feb 21, 2003·Current Opinion in Neurobiology·Zaal Kokaia, Olle Lindvall
Jun 27, 2003·The Journal of Biological Chemistry·Malika HamdaneLuc Buée
Dec 3, 2003·Cell Death and Differentiation·L A GreeneD X Liu
Dec 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Mar 23, 2004·Annals of the New York Academy of Sciences·Patrice DelobelLuc Buée
Apr 15, 2004·Current Opinion in Neurobiology·Gerd KempermannFred H Gage
May 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bin ZhangVirginia M-Y Lee
Dec 24, 2004·Biochimica Et Biophysica Acta·Nicolas SergeantLuc Buée
Feb 1, 2005·The American Journal of Pathology·Masaki IkedaDavid Westaway
Mar 3, 2005·Journal of Cell Science·Malika HamdaneLuc Buée
Apr 13, 2005·Trends in Molecular Medicine·Hyoung-Gon LeeMark A Smith
May 19, 2005·Cancer Research·Andrei L Gartel, Senthil K Radhakrishnan
Jun 3, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cathy AndorferPeter Davies
Sep 27, 2005·Experimental Cell Research·Volker RosslenbroichJoachim Kappler
Nov 18, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Martin RamsdenKaren H Ashe

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Citations

Aug 27, 2009·Journal of Neural Transmission·Kurt A Jellinger
Mar 14, 2009·Cellular and Molecular Neurobiology·Miroslava Korenova, Zuzana Stozicka
Nov 7, 2008·PloS One·Reuben SabaStephanie A Booth
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sabrina AbsalonAnna M Krichevsky
Mar 8, 2013·Seminars in Cell & Developmental Biology·Diane M Bushman, Jerold Chun
Feb 12, 2011·Journal of Neuroscience Research·Yasuhito WakasayaMikio Shoji
Nov 28, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Ozlem DemirIsil Aksan Kurnaz
Nov 28, 2014·Neuropathology and Applied Neurobiology·S DujardinL Buée
Jul 28, 2010·Biochemical Society Transactions·Luc BuéeNicolas Sergeant
Jun 18, 2016·Molecular Medicine Reports·Xueyuan LiRenzhi Wang
Oct 9, 2015·Brain Plasticity·Stefano Farioli-Vecchioli, Felice Tirone
Mar 2, 2021·Frontiers in Neurology·Sarah HoubenKunie Ando
Sep 25, 2014·ACS Chemical Neuroscience·Amrutha SwaminathanTapas K Kundu

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Methods Mentioned

BETA
transgenic
transgenics

Software Mentioned

Prism Graphpad
NIH I mage

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