Neurogenesis From Embryo to Adult - Lessons From Flies and Mice

Frontiers in Cell and Developmental Biology
Helena Mira, Javier Morante

Abstract

The human brain is composed of billions of cells, including neurons and glia, with an undetermined number of subtypes. During the embryonic and early postnatal stages, the vast majority of these cells are generated from neural progenitors and stem cells located in all regions of the neural tube. A smaller number of neurons will continue to be generated throughout our lives, in localized neurogenic zones, mainly confined at least in rodents to the subependymal zone of the lateral ventricles and the subgranular zone of the hippocampal dentate gyrus. During neurogenesis, a combination of extrinsic cues interacting with temporal and regional intrinsic programs are thought to be critical for increasing neuronal diversity, but their underlying mechanisms need further elucidation. In this review, we discuss the recent findings in Drosophila and mammals on the types of cell division and cell interactions used by neural progenitors and stem cells to sustain neurogenesis, and how they are influenced by glia.

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Citations

May 9, 2021·Stem Cells·Çağla DefteralıCarlos Vicario
Jul 25, 2021·International Journal of Molecular Sciences·Louise C Abbott, Fikru Nigussie
Jul 25, 2021·International Journal of Molecular Sciences·Citlalli NetzahualcoyotziMario Humberto Buenrostro-Jáuregui

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Methods Mentioned

BETA
scRNA-seq
sc-RNAseq
RNA-seq
transgenic

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