PMID: 22358080Feb 24, 2012Paper

Neurogenesis in the epileptic brain: a brief overview from temporal lobe epilepsy

Pharmacological Reports : PR
Marta Andres-MachJarogniew J Łuszczki

Abstract

Dentate granule cell neurogenesis persists throughout life in the hippocampus of mammals. Alterations in this process occur in many neurological diseases, including epilepsy. Among the different types of epilepsy, the most frequent is temporal lobe epilepsy (TLE). Therefore, a number of laboratory studies use animal models of TLE to observe the fate of neuronal cells after seizures. Hippocampal neurogenesis is very sensitive to physiological and pathological stimuli. Seizures, as pathological stimuli, alter both the extent and the pattern of neurogenesis, which is associated with cognitive function. Various alterations in neurogenesis are observed depending on the amount of time that has elapsed after the seizures. In acute seizures, neurogenesis generally increases, whereas in chronic epilepsy, neurogenesis decreases. Moreover, several methods currently used for the treatment of brain disorders such as TLE can also have significant impacts on cognitive functions. This review is focused on the recent findings regarding neurogenesis in animal models of TLE.

References

Jan 1, 1995·Annual Review of Neuroscience·F H GageL J Fisher
Feb 1, 1995·Italian Journal of Neurological Sciences·E A Cavalheiro
Jun 1, 1995·Experimental Neurology·F Gómez-PinillaC W Cotman
Feb 1, 1994·Brain Research. Molecular Brain Research·C M GallP J Isackson
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J BengzonO Lindvall
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Mar 11, 1999·Current Opinion in Neurobiology·S Temple, A Alvarez-Buylla
Aug 28, 1999·The Journal of Comparative Neurology·N B Hastings, E Gould
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·H van PraagF H Gage
Feb 26, 2000·Science·F H Gage
Jun 2, 2001·Journal of Neurophysiology·J S SnyderJ M Wojtowicz
Mar 5, 2002·Nature·Henriette van PraagFred H Gage
Jul 30, 2002·Progress in Brain Research·C Helmstaedter
Mar 1, 2003·Epilepsy & Behavior : E&B·Matthew R. Sarkisian
Jul 16, 2003·Journal of Neurochemistry·Owain W HowellWilliam P Gray
Dec 6, 2003·The European Journal of Neuroscience·Sebastian Jessberger, Gerd Kempermann
Apr 27, 2004·Nature·Christoph Schmidt-HieberJosef Bischofberger
Apr 28, 2004·Trends in Neurosciences·Tracey J Shors
May 26, 2004·Neuron·Karl DeisserothRobert C Malenka
Jul 15, 2004·Advances in Experimental Medicine and Biology·Susan D CrollHelen E Scharfman
Jul 28, 2004·Brain & Development·Byung Ho ChaGregory L Holmes
Sep 15, 2004·World Journal of Urology·Karl-Dietrich SievertTom F Lue
Sep 21, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·P Kwan, J W Sander
Nov 3, 2005·The European Journal of Neuroscience·Jason E KralicJean-Marc Fritschy
Jan 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chunmei ZhaoFred H Gage
Mar 8, 2006·The European Journal of Neuroscience·Sara BondeOlle Lindvall

❮ Previous
Next ❯

Citations

Aug 1, 2012·Frontiers in Biology·Yonggang Zhang, Wenhui Hu
Feb 7, 2016·Seminars in Cell & Developmental Biology·Andrew R TeeJoseph M Bateman
Sep 6, 2013·Epilepsia·Peter RotheneichnerLudwig Aigner
Jan 24, 2015·Oxidative Medicine and Cellular Longevity·Marisela Méndez-ArmentaPetra Yescas Gómez
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Sung-Joon ChoAylin Y Reid
Feb 5, 2021·Brain Research·Charles Budaszewski PintoMaria Elisa Calcagnotto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.