Neurogenesis or neuronal specification: phosphorylation strikes again!

Neuron
Helen C Lai, Jane E Johnson

Abstract

How basic helix-loop-helix (bHLH) transcription factors control neurogenesis and neuronal subtype specification through transcriptional mechanisms mediated by cell signaling remains to be fully elucidated. In this issue of Neuron, Ma et al. discover that phosphorylation via GSK3 of the bHLH factor, Ngn2 (Neurog2), adds a neuronal subtype-specific program to its functional repertoire that is activated in the developing neural tube in vivo.

Citations

Sep 15, 2010·Stem Cells and Development·Jelena BanVincent Torre
Oct 16, 2014·Neural Regeneration Research·Akintomide Apara, Jeffrey L Goldberg
Apr 8, 2016·Physiology·Cecilia Hidalgo, Alejandra Arias-Cavieres

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.