Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster.

Proceedings of the National Academy of Sciences of the United States of America
Akihiko YamamotoRobert R H Anholt

Abstract

Understanding how the genome empowers the nervous system to express behaviors remains a critical challenge in behavioral genetics. The startle response is an attractive behavioral model for studies on the relationship between genes, brain, and behavior, as the ability to respond rapidly to harmful changes in the environment is a universal survival trait. Drosophila melanogaster provides a powerful system in which genetic studies on individuals with controlled genetic backgrounds and reared under controlled environmental conditions can be combined with neuroanatomical studies to analyze behaviors. In a screen of 720 lines of D. melanogaster, carrying single P[GT1] transposon insertions, we found 267 lines that showed significant changes in startle-induced locomotor behavior. Excision of the transposon reversed this effect in five lines out of six tested. We infer that most of the 267 lines show mutant effects on startle-induced locomotion that are caused by the transposon insertions. We selected a subset of 15 insertions in the same genetic background in autosomal genes with strong mutant effects and crossed them to generate all 105 possible nonreciprocal double heterozygotes. These hybrids revealed an extensive network of epist...Continue Reading

References

Nov 1, 1996·Genetics·A MochizukiY Iwasa
Mar 4, 2000·Learning & Memory·N Schweighofer, M A Arbib
Feb 7, 2001·Genetics·T LukacsovichD Yamamoto
Nov 8, 2002·Development·Laura S Gammill, Marianne Bronner-Fraser
Dec 14, 2002·Journal of Neurogenetics·Charlotte Helfrich-FörsterJ Steven de Belle
Dec 20, 2002·Current Opinion in Neurobiology·Roland Strauss
Mar 12, 2004·Developmental Biology·Nikolaus Rajewsky, Nicholas D Socci
Nov 3, 2004·Nature Reviews. Genetics·Robert R H Anholt, Trudy F C Mackay
Nov 20, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Robert R H Anholt
Feb 3, 2005·Genetics·Bruno van Swinderen, Ralph J Greenspan
Apr 23, 2005·Journal of Neuroscience Research·Travis J WorstKent E Vrana
Apr 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Trudy F C MackayStephanie M Rollmann
Jul 19, 2005·Annual Review of Neuroscience·Ronald L Davis
Sep 6, 2005·Current Biology : CB·Carla MarguliesJosh Dubnau
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lyle E FoxChun-Fang Wu
Mar 15, 2006·Cell·Ronald H A Plasterk
Jun 20, 2006·Genetics·Katherine W JordanTrudy F C Mackay
Aug 15, 2006·Nature Genetics·Herman A Dierick, Ralph J Greenspan
Oct 19, 2006·PLoS Genetics·Alexis C EdwardsTrudy F C Mackay
Aug 22, 2007·Genome Biology·Katherine W JordanTrudy F C Mackay
Jan 11, 2008·Neuron·Philip S ChoiCatherine Dulac

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Citations

Mar 25, 2011·Genetics Research·Robert R H Anholt
Apr 13, 2011·Journal of Proteome Research·Deniz Baycin-HizalMichael J Betenbaugh
Feb 10, 2012·Nature·Trudy F C MackayRichard A Gibbs
Feb 24, 2009·Nature Genetics·Julien F AyrolesTrudy F C Mackay
Jul 9, 2009·Nature Reviews. Genetics·Trudy F C MackayJulien F Ayroles
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Liesbeth ZwartsTrudy F C Mackay
Mar 24, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Trudy F C Mackay
May 5, 2009·Genome Research·Jonathan Flint, Trudy F C Mackay
Jun 13, 2009·BMC Biology·Alexis C EdwardsTrudy F C Mackay
Aug 6, 2010·PLoS Genetics·Michael M MagwireTrudy F C Mackay
Jan 29, 2011·Genetics·Tatiana V MorozovaRobert R H Anholt
Sep 1, 2012·Annual Review of Genetics·Robert R H Anholt, Trudy F C Mackay
Jul 24, 2015·Current Opinion in Behavioral Sciences·Robert R H Anholt, Trudy F C Mackay
Dec 19, 2015·Genes, Brain, and Behavior·Xiaofang HeRobert R H Anholt
May 19, 2009·Trends in Genetics : TIG·Susan T HarbisonRobert R H Anholt
Dec 15, 2015·Nature Communications·Liesbeth ZwartsPatrick Callaerts
Aug 8, 2009·The New Phytologist·Christopher D Muir, Leonie C Moyle
Apr 20, 2012·Fly·Liesbeth ZwartsPatrick Callaerts
Jul 2, 2016·Consciousness and Cognition·Oressia Zalucki, Bruno van Swinderen
Sep 7, 2016·Parasitology International·Kenner Morais FernandesGustavo Ferreira Martins
Jun 10, 2016·PLoS Genetics·Michael J WilliamsHelgi B Schiöth
Feb 28, 2019·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Osvaldo RiveraMatthew E Talbert
Jan 27, 2019·Genetics·Hina IftikharGinger E Carney
Oct 23, 2016·G3 : Genes - Genomes - Genetics·Yanzhu LinSusan T Harbison
Jul 30, 2010·Genetics Research·Nanye LongOscar González-Recio
May 5, 2017·Genetics·Joao Picao-OsorioClaudio R Alonso
May 20, 2020·Molecular Psychiatry·Chen ZhangMing Li
Jun 7, 2018·G3 : Genes - Genomes - Genetics·Tatiana V MorozovaRobert R H Anholt
Jul 12, 2018·G3 : Genes - Genomes - Genetics·Yazmin L Serrano NegronSusan T Harbison

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