Neurogenic and non-neurogenic mechanisms of plasma extravasation in the rat

Neuroscience
P G GreenJ D Levine

Abstract

We describe two distinct mechanisms for the enhancement of plasma extravasation in the knee joint of the rat. One is activated by bradykinin and is neurogenic; the other is activated by platelet-activating factor and is non-neurogenic. Bradykinin-induced synovial plasma extravasation is known to be dependent on the sympathetic postganglionic neuron terminal, and to involve prostaglandins, ATP, adenosine A2 receptor action, and the attraction and activation of neutrophils. In this study we found that bradykinin-induced plasma extravasation also involves endothelium-derived relaxing factor; specifically we found that bradykinin-induced plasma extravasation was antagonized stereospecifically by the inhibitor of endothelium-derived relaxing factor synthesis, NG-monomethyl-L-arginine. Perfused alone, platelet-activating factor produced an increase in synovial plasma extravasation which was markedly reduced by the platelet-activating factor receptor antagonists BN 52021 and WEB 2086 (these antagonists did not affect bradykinin-induced plasma extravasation). Platelet-activating factor-induced plasma extravasation was not affected by NG-monomethyl-L-arginine, indomethacin (a prostaglandin synthesis inhibitor), phenol 3-(5H-thiozolo[2,3...Continue Reading

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Citations

Jun 23, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Kumi MoriyamaPamela Pierce Palmer
Aug 17, 1999·European Journal of Pharmacology·L R Kim, B Pomeranz
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Feb 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elizabeth K JosephJon D Levine
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Nov 19, 2010·Headache·Siwaporn ChankrachangSubsai Kongsaengdao
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Dec 24, 1998·Journal of Neurophysiology·P G GreenJ D Levine

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