Neurogenic bladder findings in patients with Congenital Zika Syndrome: A novel condition

PloS One
Lucia Maria Costa MonteiroMaria Elizabeth Lopes Moreira

Abstract

Congenital Zika Syndrome (CZS) has been associated with microcephaly and other central nervous system abnormalities including areas that have been implicated in the control of the lower urinary tract. As such, this descriptive case series has aimed to investigate whether CZS is linked with neurogenic bladder. Identifying such an association is paramount in the effort to recognize CZS complications that have putative treatment options that could mitigate the impact of CZS in infected children. Following IRB approval, urological assessment was performed in all patients referred to our clinic between June 2016 and May 2017 who presented with confirmed CZS-associated microcephaly. The research protocol consisted of obtaining clinical history, laboratory tests, lower and upper urinary tract ultrasounds, as well as a diagnostic urodynamic evaluation. ZIKA virus infection was previously confirmed by maternal history and positive PCR in babies and mothers. Microcephaly and other central nervous system abnormalities were established based on neurological assessment and associated imaging of the central nervous system (CT head and/or Brain MRI). Twenty-two consecutive CZS patients were tested and confirmed to have neurogenic bladder. Of ...Continue Reading

References

Aug 1, 1981·The Journal of Urology·E J McGuireR M Weiss
Feb 7, 2006·European Urology·Pieter DikTom P V M de Jong
Mar 3, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jameela A Kari
Dec 21, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Carla Verpoorten, Gunnar M Buyse
Jan 14, 2011·International Urology and Nephrology·Guido FillerSumit Dave
Apr 13, 2011·Clinics·Karen Previdi OlandoskiFlavio Eduardo Trigo-Rocha
Aug 19, 2011·The Journal of Urology·Beth A Drzewiecki, Stuart B Bauer
May 23, 2015·Neurourology and Urodynamics·Stuart B BauerUNKNOWN International Children's Continence Society Standardization Subcommittee
Sep 25, 2015·Emerging Infectious Diseases·Gubio S CamposSilvia I Sardi
Oct 18, 2015·The Urologic Clinics of North America·Maxim J McKibbenKristy M Borawski
Jan 29, 2016·MMWR. Morbidity and Mortality Weekly Report·Lavinia Schuler-FacciniUNKNOWN Brazilian Medical Genetics Society–Zika Embryopathy Task Force
Mar 5, 2016·The New England Journal of Medicine·Patrícia BrasilKarin Nielsen-Saines
Apr 14, 2016·The New England Journal of Medicine·Sonja A RasmussenLyle R Petersen
Apr 20, 2016·ELife·Jane P MessinaSimon I Hay
Jul 4, 2016·Lancet·Roosecelis Brasil MartinesSherif R Zaki
Jul 6, 2016·Neurology·Dafne Dain Gandelman HorovitzMarcia Cristina Bastos Boechat
Aug 24, 2016·Radiology·Patricia Soares de Oliveira-SzejnfeldFernanda Tovar-Moll
Sep 28, 2016·The Lancet Infectious Diseases·Lawrence O Gostin, James G Hodge
Nov 1, 2016·Japanese Journal of Radiology·Mohammad Zare MehrjardiAdriano N Hazin
Apr 7, 2017·MMWR. Morbidity and Mortality Weekly Report·Megan R ReynoldsUNKNOWN U.S. Zika Pregnancy Registry Collaboration
Apr 22, 2017·Jornal de pediatria·Lucia M Costa MonteiroEloane G Ramos

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Citations

Mar 29, 2019·Journal of Developmental and Behavioral Pediatrics : JDBP·Eliza Gordon-Lipkin, Georgina Peacock
Mar 12, 2020·The American Journal of Tropical Medicine and Hygiene·Rômulo A L de VasconcelosDemócrito de B Miranda-Filho
Oct 3, 2020·PLoS Neglected Tropical Diseases·Anna RamondElizabeth B Brickley
Feb 25, 2020·Journal of Biomolecular Structure & Dynamics·Carlos Alessandro FuzoRodrigo Guerino Stabeli
Sep 2, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Donald J Alcendor
Mar 11, 2020·Frontiers in Microbiology·Emanuella Meneses VenceslauUNKNOWN Zika-Unicamp Network
Jul 31, 2021·Journal of Pediatric Urology·Valéria Azevedo de AlmeidaReginaldo Antônio de Oliveira Freitas Júnior

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT03255369

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