Neurogenic differentiation of adipose derived stem cells on graphene-based mat

Materials Science & Engineering. C, Materials for Biological Applications
Zhang-Qi FengJie Zheng

Abstract

Adipose derived stem cells (ADSCs) have been proved as an abundant and accessible cell source with the ability to differentiate into neuron-like cells. However, the low differentiation efficiency puts forward an important challenge to practical applications in clinic. Considering of the good biocompatibility of graphene-based materials and the potential interaction between graphene and cells mentioned in previous studies, herein, we investigated the effect of graphene oxide (GO) and reduced graphene oxide (rGO) mats on neurogenic differentiation of the ADSCs. We demonstrated the excellent capabilities of graphene-based mats, especially GO to support the neural differentiation of ADSCs. By comparing the observation under an optical microscope and fluorescence microscope, the conversion rate of neuron-like cells reached about 90%. We consider that GO mat is better for promoting the differentiation of ADSCs into neuron-like cells, which compared to rGO based platforms. Meanwhile, we made an analysis of the mechanism by which graphene induced the differentiation of ADSCs to neuron-like cells. The data obtained here highlight the effect of GO mat on neurogenic differentiation of ADSCs and implicate the potential of graphene-based ma...Continue Reading

Citations

Jun 12, 2019·Pharmaceutics·Raluca Ioana TeleanuDaniel Mihai Teleanu
Nov 8, 2018·International Journal of Molecular Sciences·Chiara ArgentatiSabata Martino
Aug 11, 2020·Reviews in the Neurosciences·Hamidreza ArzaghiHamidreza Pazoki-Toroudi
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Gopal AgarwalAkshay Srivastava
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Amir JafariBehnaz Ashtari
Mar 17, 2021·Advanced Biology·Matteo MoschettaAndrea Capasso
May 4, 2020·Advances in Colloid and Interface Science·Sanjay TiwariPratap Bahadur
May 1, 2021·Nanomaterials·Pariya ZareAlexander M Seifalian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Liye YangChoyang Wang
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Pan-pan CHENJia-song Guo
Colloids and Surfaces. B, Biointerfaces
Jianfeng LiGordon G Wallace
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Ping YangYilin Cao
© 2022 Meta ULC. All rights reserved