Neurogenic drugs and compounds

Recent Patents on CNS Drug Discovery
Philippe Taupin

Abstract

The advent of adult neurogenesis and neural stem cell (NSC) research opens new avenues and opportunities for treating neurological diseases and disorders, particularly for the discovery and development of novel drugs. Adult neurogenesis is modulated by a broad range of stimuli, physio- and pathological processes, trophic factors/cytokines and drugs, particularly drugs used for treating neurological diseases and disorders. Hence, adult neurogenesis is the target of drugs used for treating neurological diseases and disorders, such as Alzheimer's disease and depression, and the activities of neurological drugs may be mediated by adult NSCs. Although the contribution and mechanism of adult neurogenesis and newly generated neuronal cells of the adult brain in the activities of neurological drugs remain to be determined, new research is geared toward discovering and developing novel drugs that target specifically adult neurogenesis and the NSCs of the adult brain. Neurogenic drugs may reverse or compensate deficits and impairments associated with neurological diseases and disorders, particularly those associated with the hippocampus. They may have a potential for regenerative medicine and for the treatment of brain tumors. However, l...Continue Reading

Citations

Sep 24, 2013·Molecular BioSystems·Bruno César Feltes, Diego Bonatto
Sep 6, 2013·Neurology India·Katari VenkateshPotukuchi Venkata Gurunadha Krishna Sarma
Dec 16, 2010·Expert Opinion on Therapeutic Patents·Philippe Taupin
Mar 15, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hyun-Jung Kim, Chang Yun Jin
Jan 21, 2015·Journal of Neuroscience Research·Xue-Yuan LiRen-Zhi Wang

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