PMID: 6405300Jan 1, 1983Paper

Neurogenic hypertension after depletion of norepinephrine in anterior hypothalamus induced by 6-hydroxydopamine administration into the ventral pons: role of serotonin

Neuropharmacology
E E BenarrochV E Nahmod

Abstract

Destruction of the ventral noradrenergic pathway elicited by administration of 6-hydroxydopamine (6-OHDA, 5 micrograms into each side of the ventral pons) reduced the content of norepinephrine (NE) in the anterior hypothalamus (-80%) and induced an increase in arterial blood pressure (ABP) and in heart rate. These hypertensive rats, showed hypersensitivity to the hypotensive effect of NE (0.5-2 micrograms) and clonidine (0.75-1.5 micrograms) administered into the anterior hypothalamic preoptic (AH/PO) region. Methysergide (1-2 micrograms) and, to a lesser extent, ketanserin (1-2 micrograms) administered into the anterior hypothalamic preoptic region also reduced the arterial blood pressure in these rats treated with 6-OHDA. Bilateral administration of 5,7-dihydroxytryptamine (5,7-DHT, 8 micrograms) into the median forebrain bundle decreased the content of serotonin (5-HT) in the hypothalamus (-85%) without change in arterial blood pressure but largely prevented the development of hypertension after treatment with 6-OHDA in the ventral pons. These results suggest that neurogenic hypertension is produced after the removal of NE tonic depressor activity in the anterior hypothalamus and that serotonergic mechanisms play a major rol...Continue Reading

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Citations

Aug 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·F LechinM Benaim
Nov 1, 1991·Clinical and Experimental Pharmacology & Physiology·C T YenC Y Chai
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·S N LupiV E Nahmod
Jan 1, 1986·Clinical and Experimental Hypertension. Part A, Theory and Practice·M J Meldrum, T C Westfall
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·S M DabsysV E Nahmod
Apr 1, 1988·The American Journal of the Medical Sciences·S OparilJ M Wyss
Nov 24, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Fuad LechinScarlet Baez
Oct 3, 2001·Physiological Reviews·H E de Wardener
Jan 1, 1988·Clinical and Experimental Hypertension. Part A, Theory and Practice·T KushiroN Kajiwara

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