PMID: 8971801Nov 29, 1996Paper

Neurogenic inflammation in the gastrointestinal tract of the rat

Neuroscience Letters
H SannG Jancsó

Abstract

In contrast to the skin and some visceral organs the capability of capsaicin-sensitive sensory nerves of evoking an inflammatory response in the gastrointestinal tract is equivocal. We have therefore investigated the neurogenic plasma extravasation induced by local application of capsaicin to the stomach, duodenum, jejunum, ileum and colon of the rat. Permeable vessels were visualised histologically with the vascular labelling technique using colloidal silver. In the smooth muscle layer of the small intestine, capsaicin elicited a 3-fold increase in the density of labelled blood vessels (diameter, 7-35 microns). Significant capsaicin-evoked plasma extravasation was also observed in the submucosa of the jejunum and ileum, and in the basal layer of the jejunal mucosa. Capsaicin-induced extravasation was not noted in the stomach and the colon. The data suggest the involvement of capsaicin-sensitive afferents in inflammatory processes in the rat small intestine.

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Citations

Mar 30, 2004·Autonomic Neuroscience : Basic & Clinical·Muriel LaraucheJean Fioramonti
Feb 13, 1999·Progress in Neurobiology·M J Millan
Feb 11, 1998·General Pharmacology·P Holzer
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Jun 1, 2014·The Journal of Physiology·Susan M Carlton
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May 18, 2016·The Journal of Headache and Pain·Mária DuxGábor Jancsó
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Feb 27, 2013·Nature Reviews. Gastroenterology & Hepatology·Simon J H BrookesVladimir P Zagorodnyuk
Jan 20, 2012·Pflügers Archiv : European journal of physiology·Serena MaterazziRomina Nassini
Jan 3, 2014·Physiological Reviews·Martin S SteinhoffNigel W Bunnett
Jul 7, 2007·The Journal of Pharmacology and Experimental Therapeutics·Pedro J Gomez-PinillaMaría J Pozo
Aug 15, 2019·Toxicology Mechanisms and Methods·Mohaddeseh Sadat AlaviAli Roohbakhsh
Oct 8, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nasser AbdullahChristophe Altier

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