Neurogenic pain and steroid synthesis in the spinal cord.

Journal of Molecular Neuroscience : MN
Christine Patte-MensahAyikoe Guy Mensah-Nyagan

Abstract

The spinal cord (SC) is a biosynthetic center for neurosteroids, including pregnenolone (PREG), progesterone (PROG), and 3alpha/5alpha-tetrahydroprogesterone (3alpha/5alpha-THP). In particular, an active form of cytochrome P450 sidechain cleavage (P450scc) has been localized in sensory networks of the rat SC dorsal horn (DH). P450scc is the key enzyme catalyzing the conversion of cholesterol (CHOL) into PREG, the rate-limiting step in the biosynthesis of all classes of steroids. To determine whether neurosteroidogenesis might be involved in the pivotal role played by the DH in nociception, effects of neurogenic pain provoked by sciatic nerve ligature were investigated on P450scc expression, cellular distribution, and activity in the SC. P450scc mRNA concentration was threefold higher in the DH of neuropathic rats than in controls. The nerve ligature also increased the density of P450sccpositive neuronal perykarya and fibers in the ipsilateral DH. Incubation of spinal tissue homogenates with [3H]CHOL revealed that the amount of newly synthesized [3H]PREG from [3H]CHOLwas 80% higher in the DH of neuropathic rats. Radioimmunoassays showed an increase of PREG and 3alpha/5alpha-THP concentrations in neuropathic rat DH. The upregulat...Continue Reading

Citations

Jun 9, 2012·Molecular Neurobiology·Amandine GrimmAnne Eckert
Oct 2, 2013·Neuroscience Letters·Robert P Bonin, Yves De Koninck
Jun 5, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sheu-Ran ChoiJang-Hern Lee
Jul 25, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Christine VenardChristine Patte-Mensah
Aug 21, 2013·Progress in Neurobiology·C Patte-MensahA G Mensah-Nyagan
Oct 1, 2011·Hormone Molecular Biology and Clinical Investigation·Christine Patte-MensahAyikoe Guy Mensah-Nyagan
Jun 4, 2015·Expert Opinion on Drug Discovery·Mellar P Davis
Aug 28, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cherkaouia KibalyAyikoe G Mensah-Nyagan
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Dec 19, 2014·Expert Opinion on Emerging Drugs·Eugene HsuSteven P Cohen
Aug 25, 2015·Reviews in Endocrine & Metabolic Disorders·Abdulmaged M TraishMichael Zitzmann
Sep 7, 2018·Cellular and Molecular Neurobiology·Susana Laura GonzálezAyikoe Guy Mensah-Nyagan
Dec 1, 2009·Homeopathy : the Journal of the Faculty of Homeopathy·Paolo BellaviteAnita Conforti
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Dec 2, 2020·International Journal of Molecular Sciences·Eva FalvoSilvia Giatti
Feb 6, 2021·Neuroscience and Biobehavioral Reviews·Deborah ChiabrandoEmanuela Tolosano
Sep 29, 2019·Frontiers in Neuroendocrinology·Laurence MeyerAyikoe-Guy Mensah-Nyagan
Dec 28, 2010·Pharmacology, Biochemistry, and Behavior·Mahnaz Moradi-AzaniHossein Amini
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Dec 11, 2007·Neurochemistry International·Michael SchumacherEtienne-Emile Baulieu
Apr 25, 2008·The Journal of Steroid Biochemistry and Molecular Biology·A G Mensah-NyaganC Patte-Mensah

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