Neurogenic potential of stem/progenitor-like cells in the adult mammalian eye

Progress in Retinal and Eye Research
Stefanie G WohlStefan Isenmann

Abstract

The neural retina as part of the brain has received a great deal of attention since quiescent neural stem cells/progenitor cells (NSC/PCs) were discovered in this non-neurogenic region. Herein, we particularly feature the adult rodent eye and provide an overview of all putative neuronal progenitor-like cells attributed to the various ocular areas that have been identified during the last decade. These neuronal progenitor-like cells include the pigmented cells of the ciliary body (CB), as well as the pigmented cells of the iris and the retinal pigment epithelium (RPE). Within the retina, the Müller cells, the specialized macroglia of the vertebrate eye, display neurogenic potential, i.e. de-differentiation into retinal neurons following exogenous stimulation. In addition, retinal astrocytes, which are immigrants from the brain and do not arise from a common retinal progenitor show signs of de-differentiation after injury. Interestingly, microglial cells, the immune competent cells of the central nervous system (CNS), feature neurogenic potential in vitro. Moreover, it appears that this potential can also be initially induced by injury in vivo, both in the brain and the retina. This review summarizes characteristics of various en...Continue Reading

References

Jan 1, 1979·Progress in Brain Research·H ThoenenM Schwab
Jul 1, 1992·Journal of Neurochemistry·P Louzada-JúniorJ Coutinho-Netto
Feb 10, 1992·Brain Research·E E GeisertD J Bidanset
Jan 1, 1992·The Journal of Cell Biology·D WrenM Noble
Jan 1, 1991·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·E R BüchiJ Fu
Jan 1, 1989·Annual Review of Neuroscience·R H MillerM C Raff
Feb 1, 1989·Development·G Wolswijk, M Noble
Jul 1, 1989·Developmental Biology·C M Park, M J Hollenberg
Aug 15, 1989·The Journal of Comparative Neurology·T L LingJ Stone
Apr 28, 1988·Nature·T Watanabe, M C Raff
Jan 1, 1987·Progress in Brain Research·Y A BardeH Thoenen
Jun 1, 1985·The Anatomical Record·R W Young
Feb 6, 1986·Nature·C Ffrench-Constant, M C Raff
Oct 1, 1980·Physiological Reviews·H Thoenen, Y A Barde
Jan 1, 1983·Annual Review of Physiology·Y A BardeH Thoenen
Jun 1, 1984·Journal of Neurocytology·L J MisantoneM Murray
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y A BardeH Thoenen
May 1, 1982·Experimental Neurology·B Grafstein, N A Ingoglia
Nov 1, 1994·Trends in Neurosciences·M Bähr, F Bonhoeffer
Jul 1, 1995·Experimental Eye Research·E Garcia-ValenzuelaS C Sharma
Sep 1, 1995·Experimental Eye Research·S R ShareefS C Sharma
Mar 1, 1994·Journal of Neurochemistry·M J NealJ Hogg
Apr 1, 1994·Journal of Neurobiology·E Garcia-ValenzuelaS C Sharma
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C Lois, A Alvarez-Buylla
Sep 1, 1995·Journal of Neuroscience Research·V Gallo, J T Russell
Mar 1, 1996·Archives of Ophthalmology·E B DreyerS A Lipton
Jul 1, 1996·Mayo Clinic Proceedings·T J Liesegang

❮ Previous
Next ❯

Citations

Apr 23, 2013·Trends in Neurosciences·Amanda-Jayne F CarrPeter J Coffey
Mar 29, 2013·Nature Communications·Mallika ValapalaDebasish Sinha
Jan 15, 2014·Progress in Retinal and Eye Research·Jenny R Lenkowski, Pamela A Raymond
Jun 27, 2015·Progress in Retinal and Eye Research·Elena VecinoSansar C Sharma
Dec 18, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Honghua YuDong Feng Chen
Jan 7, 2016·Glia·Stefanie Gabriele Wohl, Thomas Andrew Reh
Apr 29, 2015·Glia·Andreas Faissner, Jacqueline Reinhard
Sep 3, 2013·Journal of Cellular and Molecular Medicine·María José LuesmaLaurenţiu M Popescu
Jun 11, 2015·Journal of Cellular and Molecular Medicine·Yihua BeiJunjie Xiao
Apr 22, 2014·Experimental Eye Research·Tamami MatsushitaMasasuke Araki
Nov 29, 2013·BioMed Research International·Rebecca FrøenMorten C Moe
Apr 8, 2015·Experimental Eye Research·Nuria Sánchez-Farías, Eva Candal
Jan 16, 2015·Journal of Medicinal Chemistry·Stephen G DaviesGraham M Wynne
Jul 6, 2016·Frontiers in Neuroanatomy·Nuria Sánchez-Farías, Eva Candal
Jul 12, 2017·Journal of Anatomy·Ruth Bejarano-EscobarJavier Francisco-Morcillo
Nov 2, 2019·Current Ophthalmology Reports·Afnan M Aladdad, Karl E Kador
Jan 27, 2021·Stem Cell Research & Therapy·Kenneth N GriséDerek van der Kooy
Jul 3, 2021·International Journal of Molecular Sciences·Amanda Miles, Vincent Tropepe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Astrocytes in Repair & Regeneration

Astrocytes are glial cells found within the CNS and are able to regenerate new neurons. They become activated during CNS injury and disease. The activation leads to the transcription of new genes and the repair and regeneration of neurons. Discover the latest research on astrocytes in repair and regeneration here.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.