Neurogenically derived nitrosyl factors mediate sympathetic vasodilation in the hindlimb of the rat

The American Journal of Physiology
R L DavissonS J Lewis

Abstract

Skeletal muscle vasculature of the hindlimb is innervated by a sympathetic noncholinergic vasodilator system. The aim of this study was to determine whether this vasodilator system may represent postganglionic lumbar sympathetic neurons that synthesize and release nitric oxide (NO) or related NO-containing factors. We examined whether NO synthase (NOS)-positive postganglionic lumbar nerves innervate the hindlimb vasculature of the rat and whether the hindlimb vasodilation produced by electrical stimulation of the lumbar sympathetic chain of anesthetized rats is reduced after the systemic administration of the specific inhibitor of neuronal NOS 7-nitroindazole (7-NI). Subpopulations of lumbar sympathetic cell bodies stained intensely for NOS. Postganglionic fibers and varicosities within the iliac and femoral arteries also stained for NOS. Double ligation of the lumbar chain demonstrated that NOS was transported from the cell bodies toward the peripheral terminals. Low-intensity electrical stimulation of the lumbar chain produced a pronounced hindlimb vasodilation that was markedly diminished by pretreatment with 7-NI (45 mg/kg i.v.). In contrast, the vasodilator potency of acetylcholine and S-nitrosocysteine were augmented by 7...Continue Reading

Citations

Jun 14, 2000·American Journal of Physiology. Heart and Circulatory Physiology·A M KitchenD S O'Leary
May 2, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy KanbarClaude Julien
Sep 29, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S A WunschM D Delp
Oct 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Olga S PossasStephen J Lewis
Dec 15, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph M McClureTadeusz J Scislo
Jul 21, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tomoko K IchinoseTadeusz J Scislo
Jan 12, 2001·Physiological Reviews·J S Stamler, G Meissner
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A C AlzamoraM J Campagnole-Santos
Sep 7, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi KobaNaoyuki Hayashi
Aug 16, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Joseph M McClureTadeusz J Scislo

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