Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice.

PloS One
Guo-Jen HuangSagiv Shifman

Abstract

Several different interventions improve depressed mood, including medication and environmental factors such as regular physical exercise. The molecular pathways underlying these effects are still not fully understood. In this study, we sought to identify shared mechanisms underlying antidepressant interventions. We studied three groups of mice: mice treated with a widely used antidepressant drug--fluoxetine, mice engaged in voluntary exercise, and mice living in an enriched environment. The hippocampi of treated mice were investigated at the molecular and cellular levels. Mice treated with fluoxetine and mice who exercised daily showed, not only similar antidepressant behavior, but also similar changes in gene expression and hippocampal neurons. These changes were not observed in mice with environmental enrichment. An increase in neurogenesis and dendritic spine density was observed following four weeks of fluoxetine treatment and voluntary exercise. A weighted gene co-expression network analysis revealed four different modules of co-expressed genes that were correlated with the antidepressant effect. This network analysis enabled us to identify genes involved in the molecular pathways underlying the effects of fluoxetine and e...Continue Reading

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Citations

Mar 27, 2015·Annals of the New York Academy of Sciences·Andrew F LeuchterIan A Cook
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Datasets Mentioned

BETA
GSE6511

Methods Mentioned

BETA
Assay
PCR

Software Mentioned

Database for Annotation , Visualization , and Integrated Disco...
IterPLIER
WGCNA
R
Images
Affymetrix Expression Console
Expression Console
Affymetrix
DAVID
qvalue

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