Neuroglobin promotes neurogenesis through Wnt signaling pathway

Cell Death & Disease
Zhanyang YuXiaoying Wang

Abstract

Neuroglobin (Ngb) has been demonstrated by our lab and others to be neuroprotective against neurological disorders including stroke. However, the roles of Ngb in neurogenesis remain elusive. Neurogenesis can occur in adulthood and can be induced by pathological conditions in the brain such as stroke, and significantly contributes to functional recovery, thus enhancing endogenous neurogenesis may be a promising therapeutic strategy for neurodegenerative diseases. In this study we aimed to investigate the roles of Ngb in neurogenesis using Lentivirus overexpressing Ngb (Lv-Ngb). We show that Ngb overexpression promoted the proliferation of neural progenitor cells (NPC) marked by increased neurosphere number and size. Ngb overexpression also enhanced neuronal differentiation of cultured NPC under differentiation conditions. Moreover, subventricular injection of Lv-Ngb in mice after middle cerebral artery occlusion (MCAO) increased PSA-NCAM positive neuroblastoma cells and Tuj1 positive immature neurons, suggesting that Ngb overexpression promotes neurogenesis in mice brain after stroke. We further show that the pro-neurogenesis effect of Ngb overexpression might be mediated through Dvl1 up-regulation, and subsequent activation of ...Continue Reading

References

Oct 12, 2000·Nature·T BurmesterT Hankeln
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y SunD A Greenberg
Aug 6, 2002·Nature Medicine·Andreas ArvidssonOlle Lindvall
Nov 26, 2002·Annals of Neurology·Jack M ParentDonna M Ferriero
Mar 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yunjuan SunDavid A Greenberg
Jul 16, 2003·The Journal of Biological Chemistry·Keisuke WakasugiIsao Morishima
Dec 8, 2004·Neurobiology of Aging·Yunjuan SunDavid A Greenberg
Jun 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Maurizio BrunoriBeatrice Vallone
Oct 21, 2005·Journal of the Neurological Sciences·Jenny ChouYun Wang
Oct 28, 2005·Nature·Dieter-Chichung LieFred H Gage
Aug 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Tonya BlissGary K Steinberg
Aug 19, 2007·IUBMB Life·Karin Nienhaus, G Ulrich Nienhaus
Oct 19, 2007·Current Opinion in Pharmacology·David A GreenbergAdil A Khan
Nov 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Adil A KhanDavid A Greenberg
Dec 18, 2007·Brain Research·Richard C LiDavid Gozal
Apr 12, 2008·Stroke; a Journal of Cerebral Circulation·Xiaoying WangEng H Lo
Mar 21, 2009·Neurological Research·Zhanyang YuXiaoying Wang
Sep 19, 2009·Stroke; a Journal of Cerebral Circulation·John R SimsMichael A Moskowitz
Mar 20, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Odessa YabutGabriella D'Arcangelo
Sep 21, 2010·Nature Cell Biology·Jolly MazumdarM Celeste Simon
Dec 31, 2010·IUBMB Life·Thomas BrittainSubhadip Raychaudhuri
Feb 22, 2012·Neuroscience Letters·Bryan HainesDavid A Greenberg
May 24, 2012·The EMBO Journal·Roel Nusse, Harold Varmus
Jun 19, 2012·BMC Neuroscience·Song ZhaoXiaoying Wang
Jul 13, 2012·The Journal of Biological Chemistry·Seiji WatanabeKeisuke Wakasugi
Jul 28, 2012·International Journal of Molecular Sciences·Zhanyang YuXiaoying Wang
Sep 18, 2012·Biochimica Et Biophysica Acta·Roland Faigle, Hongjun Song
Jan 30, 2013·Biochimica Et Biophysica Acta·Marco FiocchettiMaria Marino
May 2, 2013·Oxidative Medicine and Cellular Longevity·Zhanyang YuXiaoying Wang
May 7, 2013·Neuroscience Letters·Bryan HainesDavid A Greenberg
Jul 19, 2013·Journal of Neuropathology and Experimental Neurology·Xian Shuang LiuZheng Gang Zhang
Apr 30, 2014·Stem Cells and Development·Cynthia Pérez EstradaLou Brundin
Sep 23, 2014·Cell and Tissue Research·Nibaldo C Inestrosa, Lorena Varela-Nallar
May 2, 2015·Brain Research·Ruihe Lin, Lorraine Iacovitti

❮ Previous
Next ❯

Citations

Dec 24, 2018·Nature Reviews. Cancer·Jennifer HuynhMatthias Ernst
Nov 2, 2019·Journal of Cellular and Molecular Medicine·Xiaozheng LingZhifeng Deng
Jul 1, 2020·Neural Regeneration Research·Chao ZhouChong-Jie Cheng
Nov 26, 2020·International Journal of Molecular Sciences·Morris Losurdo, Mariagrazia Grilli
Oct 11, 2020·International Journal of Molecular Sciences·Motomasa TaniokaBae Hwan Lee
Dec 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhanyang YuXiaoying Wang
Nov 13, 2019·Marine Genomics·Elizabeth R Rochon, Paola Corti
Dec 22, 2020·Neurobiology of Stress·Francisco DonosoHarriët Schellekens
Jan 6, 2022·Experimental Neurobiology·Shi-Chang CaiXiang-Shang Hu

❮ Previous
Next ❯

Methods Mentioned

BETA
mechanical dissociation
fluorescence microscopy
electrophoresis
Tracer
nuclear translocation
fluorescence imaging
gene knockout

Software Mentioned

ImageJ
Neurite Tracer

Related Concepts

Related Feeds

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.