Neurohormonal modulation of rat enterochromaffin-like cell histamine secretion

Gastroenterology
A SandorI M Modlin

Abstract

Gastric mucosal cells and nerve terminals contain at least acetylcholine, adrenergic agents, vasoactive intestinal polypeptide, calcitonin gene-related peptide, substance P, serotonin, gamma-amino-butyric acid, neurokinins A and B, neurotensin, neuropeptide Y, peptide YY, gastrin-releasing peptide, somatostatin, and [Met5]enkephalin. Although some of these agents have been implicated as regulators of gastric acid secretion, their site and mechanism of action is not well understood. The aim of this study was to investigate whether local gastric neurotransmitters modulate acid secretion by regulating basal and gastrin-driven enterochromaffin-like (ECL) cell histamine release. The effects of the above agents were investigated in a short-term 90%-95% pure ECL cell culture system. Cells were incubated with either the neuromodulator alone or in combination with gastrin for 10-40 minutes, and histamine secretion was measured by enzyme immunoassay. Acetylcholine, isoproterenol, and vasoactive intestinal polypeptide significantly stimulated basal and gastrin-driven histamine secretion, whereas calcitonin gene-related peptide and somatostatin inhibited basal and gastrin-driven histamine secretion. The M1 muscarinic receptor antagonist pi...Continue Reading

Citations

Jun 18, 1998·British Journal of Pharmacology·A K SandvikH L Waldum
Mar 30, 2000·Microscopy Research and Technique·E SolciaC Capella
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·C AthmannG Sachs
Dec 5, 2017·Experimental and Therapeutic Medicine·Xin ZhaoJia-Le Song
May 1, 1997·Scandinavian Journal of Gastroenterology·A K SandvikH I Waldum
Mar 4, 2000·Microscopy Research and Technique·E EkbladF Sundler
May 16, 2006·Digestive Diseases·Carmelo ScarpignatoFrancesco Di Mario
Apr 20, 2006·Critical Reviews in Food Science and Nutrition·M N Satyanarayana
Sep 5, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·M KiddS M Mane
Mar 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Irvin M ModlinManish C Champaneria
Apr 19, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosa María ArinBegoña Ochoa
Feb 4, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·M KiddM C Champaneria
Apr 13, 2007·Digestive Diseases and Sciences·Mohammad FayyazMichael D Sitrin
May 19, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Eleni Bitziou, Bhavik Anil Patel
Jan 11, 2013·Physiological Reviews·Sascha Kopic, John P Geibel
Jan 1, 1997·Pharmacology & Therapeutics·P Holzer, U Holzer-Petsche
Oct 2, 2002·European Journal of Pharmacology·Midori KomasakaToshihiko Murayama

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