PMID: 9416989Aug 15, 1997Paper

Neurohormonal regulation of histamine and pancreastatin secretion from isolated rat stomach ECL cells

Regulatory Peptides
E LindströmR Håkanson

Abstract

ECL cells are numerous in the acid-producing part of the rat stomach. They are rich in histamine and pancreastatin, a chromogranin A-derived peptide, and they secrete these products in response to gastrin. We have examined how isolated ECL cells respond to a variety of neuromessengers and peptide hormones. Highly purified (85%) ECL cells were collected from rat stomach using repeated counter-flow elutriation and cultured for 48 h before experiments were conducted. The ECL cells responded to gastrin, sulphated cholecystokinin-8 and to high K+ and Ca2+ with the parallel secretion of histamine and pancreastatin. Glycine-extended gastrin was without effect. Forskolin, an activator of adenylate cyclase, induced secretion, whereas isobutylmethylxanthine, a phosphodiesterase inhibitor, raised the basal release without enhancing the gastrin-evoked stimulation. Maximum stimulation with gastrin resulted in the release of 30% of the secretory products. Numerous neuromessengers and peptide hormones were screened for their ability to stimulate secretion and to inhibit gastrin-stimulated secretion. Pituitary adenylate cyclase activating peptide (PACAP)-27 and -38 stimulated secretion of both histamine and pancreastatin with a potency greater...Continue Reading

References

Dec 1, 1991·Scandinavian Journal of Gastroenterology·E Brenna, H L Waldum
Sep 1, 1985·Acta Physiologica Scandinavica·O NylanderK J Obrink
Nov 1, 1988·Scandinavian Journal of Gastroenterology·A K SandvikH L Waldum
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Jul 15, 1994·Science·C SevaT Yamada

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Citations

Jul 14, 2006·Digestive Diseases and Sciences·Koji YakabiKiyoshige Takayama
Dec 4, 2003·European Journal of Pharmacology·Tomoyuki YokotaMorikazu Onji
Jan 14, 2000·European Journal of Pharmacology·E LindströmR Håkanson
Oct 27, 1999·Regulatory Peptides·M BjörkqvistS Gammeltoft
May 14, 1999·General Pharmacology·D ChenR Håkanson
Mar 20, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Elisabetta Barocelli, Vigilio Ballabeni
Mar 14, 2001·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·E LindströmR Håkanson
Aug 28, 1998·British Journal of Pharmacology·E Lindström, R Håkanson
Jun 29, 1999·British Journal of Pharmacology·E LindströmR Håkanson
Nov 2, 2005·Inflammopharmacology·Duan ChenChun-Mei Zhao
Nov 24, 1999·The Journal of Clinical Investigation·N ZengJ R Pisegna
Nov 24, 1999·The Journal of Clinical Investigation·S A Wank
Nov 15, 2008·World Journal of Gastroenterology : WJG·Koji YakabiShingo Kato
Jun 27, 2007·British Journal of Pharmacology·E A HarperS B Kalindjian
Nov 28, 2013·Acta Physiologica·H L WaldumR Fossmark

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