Neurohumoral and ambulatory haemodynamic adaptations following isometric exercise training in unmedicated hypertensive patients

Journal of Hypertension
Katrina A TaylorJamie M O'Driscoll

Abstract

Hypertension remains the leading modifiable risk factor for cardiovascular disease. Isometric exercise training (IET) has been shown to be a useful nonpharmacological intervention for reducing resting blood pressure (BP). This study aimed to measure alterations in office BP, ambulatory BP, cardiac autonomic modulation and inflammatory and vascular biomarkers following a programme of IET in unmedicated hypertensive patients. Twenty-four unmedicated stage 1 hypertensive patients (age 43.8 ± 7.3 years; height, 178.1 ± 7 cm; weight 89.7 ± 12.8 kg) were randomly assigned in a cross-over study design, to 4-weeks of home-based IET and control period, separated by a 3-week washout period. Office and ambulatory BP, cardiac autonomic modulation, and inflammatory and vascular biomarkers were recorded pre and post-IET and control periods. Clinic and 24-h ambulatory BP significantly reduced following IET by 12.4/6.2 and 11.8/5.6 mmHg in SBP/DBP, respectively (P < 0.001 for both), compared with the control. The BP adaptations were associated with a significant (P = 0.018) reduction in the average real variability of 24-h ambulatory BP following IET, compared with control. Cardiac autonomic modulation improved by 11% (P < 0.001), baroreceptor...Continue Reading

References

Aug 1, 1991·Circulation·A MallianiS Cerutti
Oct 1, 1993·Journal of Hypertension·A FrattolaG Mancia
Apr 8, 1999·Journal of the American College of Cardiology·P ClarksonJ E Deanfield
Feb 6, 2003·Medicine and Science in Sports and Exercise·Andrea C TaylorRonald L Wiley
May 2, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Cheri L McGowanMaureen J Macdonald
Mar 13, 2009·European Journal of Applied Physiology·Jonathan Derek WilesIan L Swaine
May 27, 2010·JAMA : the Journal of the American Medical Association·Brent M EganR Neal Axon
Sep 22, 2010·Current Hypertension Reports·Kodlipet Dharmashankar, Michael E Widlansky
Apr 27, 2011·Hypertension·Charalambos AntoniadesChristodoulos Stefanadis
Mar 26, 2013·Journal of the American Heart Association·Veronique A Cornelissen, Neil A Smart
Jul 25, 2013·Journal of Sports Sciences·Natalie GoldringDamian Coleman
Mar 1, 2014·Journal of General Internal Medicine·Holly C GoodingAlison E Field
May 24, 2014·Circulation Research·Giuseppe Mancia, Guido Grassi
Jun 3, 2014·Journal of Hypertension·Gianfranco ParatiYuqing Zhang
Nov 10, 2015·The New England Journal of Medicine·UNKNOWN SPRINT Research GroupWalter T Ambrosius
Aug 12, 2016·BMJ : British Medical Journal·Sarah L StevensRichard J McManus
Nov 18, 2016·European Journal of Applied Physiology·Jonathan D WilesDamian Coleman
Jan 18, 2017·JAMA : the Journal of the American Medical Association·Mohammad H ForouzanfarChristopher J L Murray
Apr 7, 2017·Physiological Reports·Jamie M O'DriscollRajan Sharma
Jul 15, 2017·Medicine and Science in Sports and Exercise·Katrina A TaylorJamie M Oʼdriscoll

❮ Previous
Next ❯

Citations

Oct 19, 2020·European Journal of Applied Physiology·Jamie M O'DriscollJonathan D Wiles
Aug 14, 2021·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Harrison J HansfordMatthew D Jones
Jan 29, 2022·European Journal of Applied Physiology·Harry T SwiftJonathan D Wiles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.