Neurohumoral responses during prolonged exercise in humans

Journal of Applied Physiology
Lars NyboNiels H Secher

Abstract

This study examined neurohumoral alterations during prolonged exercise with and without hyperthermia. The cerebral oxygen-to-carbohydrate uptake ratio (O2/CHO = arteriovenous oxygen difference divided by arteriovenous glucose difference plus one-half lactate), the cerebral balances of dopamine, and the metabolic precursor of serotonin, tryptophan, were evaluated in eight endurance-trained subjects during exercise randomized to be with or without hyperthermia. The core temperature stabilized at 37.9 +/- 0.1 degrees C (mean +/- SE) in the control trial, whereas it increased to 39.7 +/- 0.2 degrees C in the hyperthermic trial, with a concomitant increase in perceived exertion (P < 0.05). At rest, the brain had a small release of tryptophan (arteriovenous difference of -1.2 +/- 0.3 micromol/l), whereas a net balance was obtained during the two exercise trials. Both the arterial and jugular venous dopamine levels became elevated during the hyperthermic trial, but the net release from the brain was unchanged. During exercise, the O2/CHO was similar across trials, but, during recovery from the hyperthermic trial, the ratio decreased to 3.8 +/- 0.3 (P < 0.05), whereas it returned to the baseline level of approximately 6 within 5 min af...Continue Reading

References

Jun 1, 1978·Clinical Science and Molecular Medicine·B Bigland-RitchieR H Edwards
Oct 7, 1977·Brain Research·H L Komiskey, T A Rudy
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·J M DavisW P Bartoli
Jan 1, 1986·Journal of Neural Transmission·R FavreL Peyrin
Mar 1, 1980·Acta Physiologica Scandinavica·J E Hardebo, C Owman
Oct 1, 1983·Physiological Reviews·W M Pardridge
May 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P L MadsenN A Lassen
Sep 1, 1995·Sports Medicine·R Meeusen, K De Meirleir
Jan 1, 1997·Medicine and Science in Sports and Exercise·J M Davis, S P Bailey
Jan 1, 1997·Acta Physiologica Scandinavica·E BlomstrandE A Newsholme
Apr 11, 1997·Science·M Barinaga
Jun 1, 1997·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·H K StrüderK Weber
Feb 25, 1998·Medicine and Science in Sports and Exercise·K D MittlemanS P Bailey
Mar 6, 1999·Journal of Applied Physiology·M NowakN H Secher
Mar 6, 1999·Journal of Applied Physiology·J González-AlonsoB Nielsen
Apr 10, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P L MadsenG A Dienel
Jun 15, 1999·European Journal of Applied Physiology and Occupational Physiology·J A Kent-Braun
Sep 14, 1999·Journal of Applied Physiology·J W WilliamsonJ H Mitchell
Mar 23, 2000·Progress in Neurobiology·K Ide, N H Secher
Aug 2, 2000·The American Journal of Clinical Nutrition·J M DavisR S Welsh
Sep 23, 2000·American Journal of Physiology. Endocrinology and Metabolism·E Eldrup, E A Richter
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy
Apr 20, 2001·Amino Acids·E Blomstrand
May 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·R G ShulmanD L Rothman
Aug 18, 2001·Journal of Applied Physiology·L Nybo, B Nielsen
Dec 12, 2001·Endocrine Reviews·N Ben-Jonathan, R Hnasko
Apr 17, 2002·The Journal of Physiology·Mads K DalsgaardNiels H Secher
Jun 19, 2002·Journal of Applied Physiology·Lars NyboNiels H Secher
Nov 29, 2002·The Journal of Physiology·Lars NyboBodil Nielsen
Dec 7, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gerald A DienelNancy F Cruz
Mar 7, 2003·Experimental Physiology·Mads K DalsgaardNiels H Secher
Apr 4, 2003·Medicine and Science in Sports and Exercise·Lars Nybo

❮ Previous
Next ❯

Citations

Jun 18, 2009·European Journal of Applied Physiology·Bart RoelandsRomain Meeusen
Aug 12, 2014·Pathologie-biologie·M O MelanconI J Dionne
Oct 2, 2008·Journal of the International Society of Sports Nutrition·Marios HadjicharalambousYannis P Pitsiladis
Nov 18, 2006·Annals of Biomedical Engineering·Jaeyeon KimMarco E Cabrera
Mar 25, 2011·Attention Deficit and Hyperactivity Disorders·José A MedinaMônica C Miranda
Sep 7, 2004·European Journal of Applied Physiology·Phillip WatsonRonald J Maughan
Mar 26, 2011·European Journal of Applied Physiology·Les TumiltyRhys Thatcher
Jul 8, 2011·European Journal of Applied Physiology·Heather E WrightTom M McLellan
Jul 23, 2005·The Journal of Physiology·Jukka KemppainenJuhani Knuuti
Oct 4, 2011·Progress in Neurobiology·Thomas Seifert, Niels H Secher
Dec 23, 2006·Neurobiology of Learning and Memory·Bernward WinterStefan Knecht
Sep 15, 2015·Life Sciences·Jiexiu ZhaoSantiago Lorenzo
Jul 28, 2010·Experimental Physiology·Thomas SeifertNiels H Secher
May 15, 2004·Progress in Neurobiology·Lars Nybo, Niels H Secher
Sep 1, 2009·Neurobiology of Aging·R RuscheweyhA Flöel
Nov 13, 2014·Monographs of the Society for Research in Child Development·Carol L Cheatham
Jun 7, 2014·Clinical Physiology and Functional Imaging·Andreas Fabricius-BjerreHenning B Nielsen
Apr 29, 2015·Journal of Science and Medicine in Sport·Sebastian LudygaKuno Hottenrott
Oct 6, 2015·The Journal of Physiology·Igor D Braz, James P Fisher
Jan 6, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mads K Dalsgaard
May 25, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mads K DalsgaardNiels H Secher
Jun 23, 2004·Journal of Applied Physiology·Mads K DalsgaardNiels H Secher
Jul 10, 2004·Exercise and Sport Sciences Reviews·Stephen S Cheung, Gordon G Sleivert
Sep 11, 2004·Journal of Applied Physiology·Samuel N CheuvrontMichael N Sawka
Jan 15, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Phillip WatsonRonald J Maughan
Mar 31, 2007·Journal of Neuroscience Research·Mads K Dalsgaard, Niels H Secher
Aug 29, 2007·Sports Medicine·Jordan S Querido, A William Sheel
Jul 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T SeifertH B Nielsen
Nov 5, 2011·Medicine and Science in Sports and Exercise·Michel O MelanconIsabelle J Dionne
Apr 11, 2012·European Journal of Applied Physiology·Andres BurkVahur Oöpik
Sep 29, 2012·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Gang SunLun Zhao
Feb 26, 2008·Current Sports Medicine Reports·Jonathan T Finnoff
Jan 22, 2005·Current Sports Medicine Reports·Eric J Anish
May 24, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Peter RasmussenCarsten Lundby
Nov 12, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Takeshi HashimotoShigehiko Ogoh
Sep 29, 2006·Sports Medicine·Romain MeeusenMaria F Piacentini
Nov 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Samuel N CheuvrontMichael N Sawka

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.