PMID: 8960813Dec 1, 1996Paper

Neurohypophysial peptides. Histaminergic regulation and function in adenohypophysial secretion

Danish Medical Bulletin
A Kjaer

Abstract

Stress stimulates the secretion of the pro-opiomelanocortin (POMC) derived peptides ACTH and beta-endorphin (beta-END) as well as prolactin (PRL) from the adenohypophysis. The regulation of adenohypophysial hormone secretion is complex and includes a variety of neuropeptides and neuroamines. Histamine (HA) seems to participate as a neurotransmitter in the central regulation of adenohypophysial secretion and is involved in stress-induced release of these hormones. However, the effect of HA on POMC and PRL secretion is indirect and may involve activation of hypothalamic neurons subsequently releasing hypophysiotropic factors that in turn regulate adenohypophysial hormone secretion. In addition to the major hypothalamic factors regulating POMC and PRL secretion, corticotropin-releasing hormone and dopamine, the neurohypophysial peptides arginine-vasopressin (AVP) and oxytocin (OT) may serve such a regulatory role in adenohypophysial hormone secretion. We investigated this hypothesis at two different levels by a series of experiments presented in this review. The experiments aimed at studying: 1) the possible role of HA as a neuroendocrine regulator of AVP and OT secretion and neuronal activation, and 2) the possible involvement of...Continue Reading

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