Neuroimaging abnormalities in individuals exhibiting Parkinson's disease risk markers

Movement Disorders : Official Journal of the Movement Disorder Society
Marcus HeldmannNorbert Brüggemann

Abstract

The concept of prodromal Parkinson's disease (PD) involves variable combinations of nonmotor features and subtle motor abnormalities as a result of ongoing neurodegeneration in the brain stem including substantia nigra (SN) and abnormal findings upon transcranial sonography and nuclear imaging. Except for nuclear imaging, the predictive value of risk markers for the conversion to overt PD is low. The objective of this study was to determine whether PD risk markers are associated with changes in brain structure and to what extent cognitive changes are risk markers for PD. Diffusion-weighted imaging, voxel-based morphometry, and cortical thickness analysis was performed in 29 individuals with hyposmia and/or an increased SN hyperechogenicity (SN+) upon transcranial sonography and 28 controls without these 2 risk markers. Classical parkinsonian signs were an exclusion criterion. All of the participants underwent a neuropsychological test battery addressing executive functions, learning ability, and verbal fluency. In the PD risk group, diffusion-weighted imaging mean diffusivity was increased in 4 left hemisphere clusters (posterior thalamus, inferior longitudinal fasciculus, fornix, corticospinal tract). A negative relationship o...Continue Reading

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Citations

Jun 19, 2019·Journal of Neurosurgical Sciences·Edson Bor-Seng-ShuUwe Walter
Oct 13, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·David E Vaillancourt, Stéphane Lehericy
Jun 19, 2019·Annals of Clinical and Translational Neurology·Alexander BalckChristine Klein
Jun 18, 2020·Frontiers in Neurology·Bruce A Chase, Katerina Markopoulou
Feb 14, 2021·British Journal of Clinical Pharmacology·Yucheng ShengChao Chen

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