Neuroimaging and Neuropsychological Outcomes Following Clinician-Delivered Cognitive Training for Six Patients With Mild Brain Injury: A Multiple Case Study

Frontiers in Human Neuroscience
Amy Lawson MooreChristina Ledbetter

Abstract

Nearly half of all mild brain injury sufferers experience long-term cognitive impairment, so an important goal in rehabilitation is to address their multiple cognitive deficits to help them return to prior levels of functioning. Cognitive training, or the use of repeated mental exercises to enhance cognition, is one remediation method for brain injury. The primary purpose of this hypothesis-generating pilot study was to explore the statistical and clinical significance of cognitive changes and transfer of training to real-life functioning following 60 h of Brain Booster, a clinician-delivered cognitive training program, for six patients with mild traumatic brain injury (TBI) or non-traumatic acquired brain injury (ABI). The secondary purpose was to explore changes in functional connectivity and neural correlates of cognitive test gains following the training. We used a multiple case study design to document significant changes in cognitive test scores, overall IQ score, and symptom ratings; and we used magnetic resonance imaging (MRI) to explore trends in functional network connectivity and neural correlates of cognitive change. All cognitive test scores showed improvement with statistically significant changes on five of the s...Continue Reading

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References

Apr 8, 1998·Annual Review of Neuroscience·D V Buonomano, M M Merzenich
Sep 21, 2004·The Journal of Neuropsychiatry and Clinical Neurosciences·Jeremy D Schmahmann
Feb 18, 2005·Journal of Neurophysiology·A Floyer-Lea, P M Matthews
Nov 28, 2007·Emotion·Lara G ChepenikMartha J Farah
Oct 7, 2008·NeuroImage·Catherine J Stoodley, Jeremy D Schmahmann
Oct 28, 2008·Brain : a Journal of Neurology·Sumit N NiogiBruce D McCandliss
Mar 24, 2009·The Mount Sinai Journal of Medicine, New York·Theodore Tsaousides, Wayne A Gordon
Jul 3, 2010·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Masayuki MorikawaToshifumi Kishimoto
Jul 16, 2010·Trends in Cognitive Sciences·Torkel Klingberg
May 17, 2011·Journal of Autism and Developmental Disorders·Matteo PardiniLeonardo Emberti Gialloreti
Aug 16, 2011·Brain : a Journal of Neurology·David J SharpRobert Leech
Nov 15, 2011·Human Brain Mapping·Dietsje D JollesSerge A R B Rombouts
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
May 31, 2012·Brain Connectivity·Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon
Mar 26, 2013·Nurse Researcher·Catherine HoughtonKathy Murphy
May 8, 2013·Brain : a Journal of Neurology·Rebecca J Von Der HeideIngrid R Olson
Dec 18, 2013·Frontiers in Human Neuroscience·Laura FerreriAurelia Bugaiska
Dec 18, 2013·Human Brain Mapping·Hikaru TakeuchiRyuta Kawashima
Feb 12, 2014·Nature Reviews. Neurology·David J SharpRobert Leech
Jan 27, 2015·PLoS Biology·Aurélie Ernst, Jonas Frisén
Feb 24, 2015·Handbook of Clinical Neurology·Mary Alexis IaccarinoRoss Zafonte
Feb 19, 2016·Journal of the International Neuropsychological Society : JINS·Kihwan HanDaniel C Krawczyk
Jun 9, 2016·International Journal of Epidemiology·Jisca S KuiperNynke Smidt
Jul 15, 2016·Disability and Rehabilitation·Bhanu SharmaRobin E A Green
Nov 12, 2016·Frontiers in Human Neuroscience·Harry HallockMichael Valenzuela
Nov 22, 2016·Applied Cognitive Psychology·Dick M CarpenterAmy Lawson Moore
Jun 24, 2018·The Journal of Pediatrics·Christopher G WatsonMichael J Rivkin
Mar 31, 2019·Archives of Physical Medicine and Rehabilitation·Keith D CiceroneJ Preston Harley
Aug 23, 2019·Neurorehabilitation and Neural Repair·Kihwan HanDaniel C Krawczyk
Aug 30, 2019·Journal of Clinical Medicine·Eunkyung KimByung-Mo Oh

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Key Resources (RRID) Mentioned

SCR_009550

Software Mentioned

Number Series
CONN Toolbox
TRActs Constrained by UnderLying Anatomy ( TRACULA )
TRACULA
CONN aCompCor
CONN artifact reduction tool ART
FreeSurfer
aCompCor
LearningRx
Brain Booster

Related Concepts

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Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.