Neuroimaging and quality-of-life outcomes in patients with brain metastasis and peritumoral edema who undergo Gamma Knife surgery

Journal of Neurosurgery
Hung-Chuan PanJason Sheehan

Abstract

Gamma Knife surgery (GKS) has been shown to be effective for treating many patients with brain metastasis. Some brain metastases demonstrate significant peritumoral edema; radiation may induce cerebral edema or worsening preexisting edema. This study was conducted to evaluate the imaging and neurobehavioral outcomes in patients with preexisting peritumoral edema who then undergo GKS. Between August 2003 and January 2008, 63 cases of brain metastasis with significant peritumoral edema (> 20 cm(3)) were prospectively studied. The study inclusion criteria were as follows: 1) a single metastatic lesion with significant edema (perilesional edema signal volume on FLAIR > 20 cm(3)); and 2) inclusion of only 1 lesion > 20 cm(3) in the study (in cases of multiple lesions noted on FLAIR images). All patients received MR imaging with pulse sequences including T1-weighted imaging and FLAIR with or without contrast and T2-weighted imaging at an interval of 3 months. A neurological assessment and Brain Cancer Module (BCM-20) questionnaire were obtained every 2-3 months. Kaplan-Meier, Cox regression, and logistic regression were used for analysis of survival and associated factors. At the time of GKS, the median Karnofsky Performance Scale (K...Continue Reading

Citations

Jun 27, 2015·Journal of Neurosurgery·Jason P SheehanDavid Schlesinger
Sep 17, 2011·AJNR. American Journal of Neuroradiology·T R PatelV L Chiang
Dec 4, 2019·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Eline VerhaakMargriet M Sitskoorn
Feb 21, 2014·Expert Review of Neurotherapeutics·Drexell Hunter BoggsMinesh P Mehta
Sep 4, 2015·Journal of Neuro-oncology·Jason P SheehanL Dade Lunsford
May 12, 2015·British Journal of Neurosurgery·Sang Ryul LeeSe-Hyuk Kim
Feb 12, 2011·Neurosurgery·Huai-che YangDouglas Kondziolka
May 4, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·E OldenburgerK Haustermans

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