Neuroimaging as a New Diagnostic Modality in Amyotrophic Lateral Sclerosis

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Esther Verstraete, Bradley R Foerster

Abstract

Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of upper and lower motor neurons, with variable involvement of extramotor brain regions. Currently, there are no established objective markers of upper motor neuron and extramotor involvement in ALS. Here, we review the potential diagnostic value of advanced neuroimaging techniques that are increasingly being used to study the brain in ALS. First, we discuss the role of different imaging modalities in our increasing understanding of ALS pathogenesis, and their potential to contribute to objective upper motor neuron biomarkers for the disease. Second, we discuss the challenges to be overcome and the required phases of diagnostic test development to translate imaging technology to clinical care. We also present examples of multidimensional imaging approaches to achieve high levels of diagnostic accuracy. Last, we address the role of neuroimaging in clinical therapeutic trials. Advanced neuroimaging techniques will continue to develop and offer significant opportunities to facilitate the development of new effective treatments for ALS.

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Citations

Mar 22, 2015·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stacey A Sakowski, Eva L Feldman
Jun 14, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·William HuynhMatthew C Kiernan
Apr 19, 2018·Expert Review of Neurotherapeutics·Thanuja DharmadasaMatthew C Kiernan
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Dec 20, 2018·Frontiers in Neurology·Andrew W BarrittP Nigel Leigh
Jun 8, 2017·Arquivos de neuro-psiquiatria·Antônio José da Rocha, Marco Antonio Chieia
Jan 4, 2019·Neuroinformatics·Paola GaldiFabrizio Esposito

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