Neuroimaging as a tool to study the sources of phenotypic heterogeneity in Huntington's disease

Current Opinion in Neurology
Clara Garcia-GorroRuth de Diego-Balaguer

Abstract

Huntington's disease is a neurodegenerative disorder characterized by a triad of motor, cognitive and psychiatric disturbances. There is great variability regarding the prominence and evolution of each type of clinical sign. One possible source of phenotypic heterogeneity could be the more prominent degeneration of specific brain circuits. The scope of this review is to highlight the most recent neuroimaging studies that have analysed the relationship between brain changes and motor, cognitive and psychiatric alterations in Huntington's disease. The results from recent neuroimaging studies are heterogeneous. Although there is a great overlap between the different regions associated with each symptomatic domain, there is some degree of differentiation. For example, the motor network is associated with motor impairment, whereas the ventral striatum is especially involved in emotional deficits related with psychiatric problems. Motor, cognitive and psychiatric impairments are associated with structural and functional brain biomarkers. However, the specificity of the regions involved remains unknown, because these studies focused on specific regions and symptoms. In order to tease apart the neural substrates that underlie the pheno...Continue Reading

References

Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·J P VonsattelE P Richardson
Dec 1, 1988·Brain : a Journal of Neurology·K PodollJ Noth
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Aug 1, 1995·Journal of Medical Genetics·N K RosenbergA L Christensen
Mar 1, 1996·Movement Disorders : Official Journal of the Movement Disorder Society
Jul 29, 1998·Brain : a Journal of Neurology·A D LawrenceB J Sahakian
Aug 29, 2001·Neurology·J S PaulsenUNKNOWN Huntington Study Group
Dec 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Jean-Pascal LefaucheurFabrice Lisovoski
Jan 20, 2004·Journal of Chemical Neuroanatomy·Suzanne N Haber
Apr 20, 2004·Brain : a Journal of Neurology·A HennenlotterA O Ceballos-Baumann
Mar 25, 2005·Brain : a Journal of Neurology·Marc TeichmannAnne-Catherine Bachoud-Lévi
Jun 17, 2005·European Child & Adolescent Psychiatry·Michal HrdlickaTomas Urbanek
Sep 13, 2005·Journal of Communication Disorders·Angela M JensenDavid A Copland
May 23, 2006·Nature Reviews. Neuroscience·Henry H Yin, Barbara J Knowlton
Sep 23, 2006·Journal of Cognitive Neuroscience·Marc TeichmannAnne-Catherine Bachoud-Lévi
Dec 21, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·Camille L JulienDavid Craufurd
Feb 17, 2007·Neuropsychologia·Andrea C SolomonUNKNOWN Predict-HD investigators of the Huntington Study Group
May 8, 2007·Biological Psychiatry·Kevin DuffUNKNOWN Predict-HD Investigators of the Huntington Study Group
Dec 22, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·J S PaulsenUNKNOWN Predict-HD Investigators and Coordinators of the Huntington Study Group
Feb 23, 2008·General Hospital Psychiatry·Elisabeth M KingmaRaymund A C Roos
Mar 13, 2008·Brain : a Journal of Neurology·Marc TeichmannAnne-Catherine Bachoud-Lévi
Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bogdan DraganskiRichard S J Frackowiak
Oct 10, 2008·Brain : a Journal of Neurology·R De Diego-BalaguerA-C Bachoud-Lévi
Apr 9, 2010·Brain : a Journal of Neurology·Doris C V ThuRichard L M Faull
Jun 15, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Susanne A SchneiderMarjan Jahanshahi
Aug 7, 2010·Neurobiology of Disease·Peggy C NopoulosUNKNOWN PREDICT-HD Investigators Coordinators of Huntington Study Group (HSG)
Oct 6, 2010·Neuropsychology·Julie C StoutElizabeth H Aylward
Oct 1, 1998·Trends in Cognitive Sciences·A D LawrenceT W Robbins
Mar 17, 2011·Journal of Psychiatry & Neuroscience : JPN·Rottraut IlleAnne Schienle
Aug 24, 2011·Current Neurology and Neuroscience Reports·Jane S Paulsen
Apr 5, 2012·Proceedings of the National Academy of Sciences of the United States of America·Damien A FairJoel T Nigg
Apr 17, 2012·Brain : a Journal of Neurology·Marianne J U NovakSarah J Tabrizi
Sep 15, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Zhihong GuoJuan C Troncoso
Mar 14, 2013·Social Cognitive and Affective Neuroscience·Imis DoganKathrin Reetz

❮ Previous
Next ❯

Citations

Oct 30, 2020·Frontiers in Systems Neuroscience·Alicia Palomar-Garcia, Estela Camara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Journal of Huntington's Disease
Mads Abildtrup, Michael Shattock
Neurophysiologie clinique = Clinical neurophysiology
A DelvalL Defebvre
© 2022 Meta ULC. All rights reserved