DOI: 10.1101/19002147Aug 26, 2019Paper

Neuroimaging biomarkers differentiate Parkinson disease with and without cognitive impairment and dementia

MedRxiv : the Preprint Server for Health Sciences
Conor Owens-WaltonO. Hansson


Mild cognitive impairment in Parkinson disease places a high burden on patients and is likely a precursor to Parkinson disease-related dementia. Studying the functional connectivity and morphology of subcortical structures within basal ganglia-thalamocortical circuits may uncover neuroimaging biomarkers of cognitive dysfunction in PD. We used an atlas-based seed region-of-interest approach to investigate resting-state functional connectivity of important subdivisions of the caudate nucleus, putamen and thalamus, between controls (n = 33), cognitively unimpaired Parkinson disease subjects (n = 33), Parkinson disease subjects with mild cognitive impairment (n = 22) and Parkinson disease subjects with dementia (n = 17). We then investigated how the morphology of the caudate, putamen and thalamus structures and differed between groups. Results indicate that cognitively unimpaired Parkinson disease subjects, compared to controls, display increased functional connectivity of the dorsal caudate, anterior putamen and mediodorsal thalamic subdivisions with areas across the frontal lobe, as well as reduced functional connectivity of the dorsal caudate with posterior cortical and cerebellar regions. Compared to controls, Parkinson disease...Continue Reading

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