Neuroimaging Correlates of Suicidality in Decision-Making Circuits in Posttraumatic Stress Disorder

Frontiers in Psychiatry
Jennifer BarredoNoah S Philip

Abstract

In depression, brain and behavioral correlates of decision-making differ between individuals with and without suicidal thoughts and behaviors. Though promising, it remains unknown if these potential biomarkers of suicidality will generalize to other high-risk clinical populations. To preliminarily assess whether brain structure or function tracked suicidality in individuals with posttraumatic stress disorder (PTSD), we measured resting-state functional connectivity and cortical thickness in two functional networks involved in decision-making, a ventral fronto-striatal reward network and a lateral frontal cognitive control network. Neuroimaging data and self-reported suicidality ratings, and suicide-related hospitalization data were obtained from 50 outpatients with PTSD and also from 15 healthy controls, and all were subjected to seed-based resting-state functional connectivity and cortical thickness analyses using a priori seeds from reward and cognitive control networks. First, general linear models (GLM) were used to evaluate whether ROI-to-ROI functional connectivity was predictive of self-reported suicidality after false discovery rate (FDR)-correction for multiple comparisons and covariance of age and depression symptoms....Continue Reading

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Citations

Nov 5, 2019·The Spanish Journal of Psychology·Pablo Ezequiel Flores-KanterLeonardo Adrián Medrano
Dec 4, 2019·The European Journal of Neuroscience·Aiste LengvenyteEmilie Olié
Jun 20, 2020·Translational Psychiatry·Amin ZandvakiliNoah S Philip
Jan 14, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Jessica R GilbertCarlos A Zarate
Feb 8, 2021·Journal of Affective Disorders·Anna StumpsMichael Esterman
Mar 3, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Jennifer BarredoNoah S Philip
Apr 7, 2021·Biological Psychiatry·Jennifer BarredoNoah S Philip
Jul 7, 2021·Journal of Personality Assessment·Pablo Ezequiel Flores-KanterJesús M Alvarado

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Key Resources (RRID) Mentioned

SCR_009550

Software Mentioned

Anatomy Toolbox
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SPM Anatomy Toolbox
MATLAB
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Freesurfer

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