Abstract
Incidence and patterns of brain lesions of sepsis-induced brain dysfunction (SIBD) have been well defined. Our objective was to investigate the associations between neuroimaging features of SIBD patients and well-known neuroinflammation and neurodegeneration factors. In this prospective observational study, 93 SIBD patients (45 men, 48 women; 50.6 ± 12.7 years old) were enrolled. Patients underwent a neurological examination and brain magnetic resonance imaging (MRI). Severity-of-disease scoring systems (APACHE II, SOFA, and SAPS II) and neurological outcome scoring system (GOSE) were used. Also, serum levels of a panel of mediators [IL-1β, IL-6, IL-8, IL-10, IL-12, IL-17, IFN-γ, TNF-α, complement factor Bb, C4d, C5a, iC3b, amyloid-β peptides, total tau, phosphorylated tau (p-tau), S100b, neuron-specific enolase] were measured by ELISA. Voxel-based morphometry (VBM) was employed to available patients for assessment of neuronal loss pattern in SIBD. MRI of SIBD patients were normal (n = 27, 29%) or showed brain lesions (n = 51, 54.9%) or brain atrophy (n = 15, 16.1%). VBM analysis showed neuronal loss in the insula, cingulate cortex, frontal lobe, precuneus, and thalamus. Patients with abnormal MRI findings had worse APACHE II, ...Continue Reading
References
Mar 1, 1975·Lancet·B Jennett, M Bond
Aug 1, 1992·Archives of Neurology·R SchmidtH Lechner
Jan 1, 1992·Scandinavian Journal of Infectious Diseases·A S DofferhoffJ Weits
Dec 26, 2001·JAMA : the Journal of the American Medical Association·E W ElyR Dittus
Mar 30, 2002·Annals of Surgery·Heike WeighardtBernhard Holzmann
Nov 8, 2002·American Journal of Respiratory and Critical Care Medicine·Curtis N SesslerR K Elswick
Jun 10, 2003·Critical Care Medicine·Zoltán SpolaricsEdwin A Deitch
Dec 5, 2003·Lancet·Tarek SharsharDjillali Annane
Mar 5, 2004·Brain Pathology·Tarek SharsharGray Françoise
Apr 15, 2004·JAMA : the Journal of the American Medical Association·E Wesley ElyRobert S Dittus
Oct 7, 2004·European Journal of Pharmacology·Robert Dantzer
Apr 9, 2005·Epilepsia·Robert S FisherJerome Engel
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susana E MorenoFoo Y Liew
Mar 23, 2007·Intensive Care Medicine·Tarek SharsharDjillali Annane
Jan 10, 2009·Neurochemical Research·Ornella PiazzaRosalba Tufano
Feb 3, 2009·Clinics in Chest Medicine·Ramona O Hopkins, James C Jackson
Feb 6, 2010·Critical Care Medicine·Emanuele IacoboneTarek Sharshar
May 4, 2010·Mayo Clinic Proceedings·Jennifer E FugateAlejandro A Rabinstein
May 18, 2010·Critical Care Medicine·Timothy D GirardE Wesley Ely
May 27, 2010·Brain Imaging and Behavior·Mary R SuchytaRamona O Hopkins
Jul 1, 2010·Journal of Innate Immunity·Peter A Ward
Oct 28, 2010·JAMA : the Journal of the American Medical Association·Theodore J IwashynaKenneth M Langa
Sep 24, 2011·Critical Care : the Official Journal of the Critical Care Forum·Huang-Pin WuDuen-Yau Chuang
Jun 20, 2012·Critical Care Medicine·Max L GuntherUNKNOWN VISIONS Investigation, VISualizing Icu SurvivOrs Neuroradiological Sequelae
Sep 19, 2012·Nature Reviews. Neurology·Teneille E Gofton, G Bryan Young
Nov 9, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Alexander SemmlerMichael T Heneka
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Feb 16, 2013·Expert Review of Anti-infective Therapy·Nicolas AdamTarek Sharshar
May 31, 2013·Annals of Intensive Care·Romain SonnevilleTarek Sharshar
Sep 21, 2013·Critical Care : the Official Journal of the Critical Care Forum·Andrea PolitoTarek Sharshar
Feb 5, 2015·Neurocritical Care·Raoul SutterRobert D Stevens
Apr 18, 2015·Brain, Behavior, and Immunity·Sven BensonSigrid Elsenbruch
May 27, 2015·Shock·Romain SonnevilleIlse Vanhorebeek
Nov 12, 2015·Brain Research·Vikram PuvennaDamir Janigro
Nov 26, 2015·Brain, Behavior, and Immunity·Franziska LabrenzSven Benson
May 28, 2016·Clinics in Chest Medicine·Aurelien MazeraudTarek Sharshar
Jul 6, 2016·Brain Pathology·Gabor G KovacsBeata Sikorska
Nov 12, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jordan WarfordAlexander S Easton
Oct 24, 2017·Critical Care : the Official Journal of the Critical Care Forum·Johannes EhlerAxel Petzold
Nov 12, 2017·The Journal of Biological Chemistry·Juciano GasparottoDaniel P Gelain
Citations
Jun 13, 2019·Neurocritical Care·Günseli OrhunFigen Esen
Sep 15, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Figen EsenErdem Tüzün
Mar 17, 2020·EMBO Molecular Medicine·Jean-Marc CavaillonTomasz Skirecki
Jun 5, 2020·The European Journal of Neuroscience·Gundula SeidelFarsin Hamzei
Nov 26, 2019·Shock·Mabel N AbrahamClifford S Deutschman
Dec 11, 2020·International Journal of Emergency Medicine·Hale TokluEnrique Serrano
Jul 10, 2020·Brain : a Journal of Neurology·Francisco Hernández-FernándezTomás Segura
Apr 15, 2021·The International Journal of Neuroscience·Günseli OrhunErdem Tüzün
Jul 9, 2021·Nature and Science of Sleep·In-Ae SongTak Kyu Oh
Jul 1, 2021·Seminars in Immunopathology·Marco MannesMarkus Huber-Lang