Neuroimaging in epilepsy

Current Opinion in Neurology
Meneka Kaur SidhuJosemir W Sander

Abstract

Epilepsy neuroimaging is important for detecting the seizure onset zone, predicting and preventing deficits from surgery and illuminating mechanisms of epileptogenesis. An aspiration is to integrate imaging and genetic biomarkers to enable personalized epilepsy treatments. The ability to detect lesions, particularly focal cortical dysplasia and hippocampal sclerosis, is increased using ultra high-field imaging and postprocessing techniques such as automated volumetry, T2 relaxometry, voxel-based morphometry and surface-based techniques. Statistical analysis of PET and single photon emission computer tomography (STATISCOM) are superior to qualitative analysis alone in identifying focal abnormalities in MRI-negative patients. These methods have also been used to study mechanisms of epileptogenesis and pharmacoresistance.Recent language fMRI studies aim to localize, and also lateralize language functions. Memory fMRI has been recommended to lateralize mnemonic function and predict outcome after surgery in temporal lobe epilepsy. Combinations of structural, functional and post-processing methods have been used in multimodal and machine learning models to improve the identification of the seizure onset zone and increase understandin...Continue Reading

References

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Citations

May 21, 2019·Current Opinion in Neurology·Roland Wiest, Roland Beisteiner
Oct 18, 2019·Neurosurgery·Kristine RavinaJonathan J Russin
Nov 9, 2019·F1000Research·Christoph BaumgartnerSusanne Pirker
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Jan 28, 2020·Seizure : the Journal of the British Epilepsy Association·Ho-Joon Lee, Kang Min Park
Apr 3, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Alessandro ConsalesCarlo Efisio Marras
Oct 20, 2019·Behavioural Brain Research·Laetitia Chauvière
May 7, 2021·Epilepsy & Behavior : E&B·Ayataka FujimotoTohru Oanishi
Dec 15, 2020·Seminars in Ultrasound, CT, and MR·Korbin M DavisJustin B Sims
Jun 11, 2021·Journal of Neuroscience Research·Enes AkyüzMohd Farooq Shaikh
Jun 28, 2021·Epilepsy Research·Franz RiedererChristoph Baumgartner
Jul 10, 2021·Frontiers in Neuroscience·Daichi Sone, Iman Beheshti
Jul 4, 2021·Journal of the Neurological Sciences·Wesley T KerrJohn M Stern
Jun 27, 2021·Journal of the Neurological Sciences·Nathan A ShlobinJosemir W Sander

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Methods Mentioned

BETA
surface

Software Mentioned

MIM
MIMneuro
STATISCOM
SISCOM

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