Neuroimaging in Restless Legs Syndrome

Sleep Medicine Clinics
Federica Provini, Giacomo Chiaro

Abstract

Neuroimaging studies are of crucial relevance in defining the pathophysiology of restless legs syndrome (RLS). MRI studies showed no structural brain lesions and confirmed a central iron deficiency. Structural and functional studies showed an involvement of the thalamus, sensorimotor cortical areas, and cerebellum in RLS and assessed neurotransmission abnormalities in the dopaminergic and opiate systems. Finally, glutamatergic hyperactivity has been proposed as a cause of disrupted and shortened sleep in RLS. Differences among the results of the studies make it difficult to draw any definitive conclusions, thus, suggesting the need for future research.

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Citations

Feb 15, 2017·Clinical Nuclear Medicine·Jessica OhnonaJean-Noël Talbot
Apr 27, 2018·Neurology·Tadaaki Mano, Robert J Thomas
Sep 16, 2020·Der Nervenarzt·Michael BartlFrie de Ri Ke Sixel-Döring
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Sep 15, 2019·Neuroscience Letters·Rui ZhangAnn-Kathrin Stock
May 15, 2021·Sleep Medicine Clinics·Celia Garcia-MaloIrene Cano-Pumarega

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