Neuroimaging in the Diagnosis of Chronic Traumatic Encephalopathy: A Systematic Review

Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine
Philip SparksStephan Hinze

Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repeated subconcussive and concussive head injury. Clinical features include cognitive, behavioral, mood, and motor impairments. Definitive diagnosis is only possible at postmortem. Here, the utility of neuroimaging in the diagnosis of CTE is evaluated by systematically reviewing recent evidence for changes in neuroimaging biomarkers in suspected cases of CTE compared with controls. Providing an update on a previous systematic review of articles published until December 2014, we searched for articles published between December 2014 and July 2016. We searched PubMed for studies assessing neuroimaging changes in symptomatic suspected cases of CTE with a history of repeated subconcussive or concussive head injury or participation in contact sports involving direct impact to the head. Exclusion criteria were case studies, review articles, and articles focusing on repetitive head trauma from military service, head banging, epilepsy, physical abuse, or animal models. Seven articles met the review criteria, almost all of which studied professional athletes. The range of modalities were categorized into structural magnetic resonance imaging (MRI), d...Continue Reading

Citations

Jul 10, 2019·The British Journal of Radiology·Julian D DallmeierCyrus A Raji
Mar 24, 2018·Case Reports in Neurological Medicine·Shauna H Yuan, Sonya G Wang
May 21, 2018·Brain Imaging and Behavior·Christian LepageInga K Koerte

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