Neuroimaging Mechanisms of Therapeutic Transcranial Magnetic Stimulation for Major Depressive Disorder

Biological Psychiatry : Cognitive Neuroscience and Neuroimaging
Noah S PhilipLinda L Carpenter

Abstract

Research into therapeutic transcranial magnetic stimulation (TMS) for major depression has dramatically increased in the last decade. Understanding the mechanism of action of TMS is crucial to improve efficacy and develop the next generation of therapeutic stimulation. Early imaging research provided initial data supportive of widely held assumptions about hypothesized inhibitory or excitatory consequences of stimulation. Early work also indicated that while TMS modulated brain activity under the stimulation site, effects at deeper regions, in particular, the subgenual anterior cingulate cortex, were associated with clinical improvement. Concordant with earlier findings, functional connectivity studies also demonstrated that clinical improvements were related to changes distal, rather than proximal, to the site of stimulation. Moreover, recent work suggests that TMS modulates and potentially normalizes functional relationships between neural networks. An important observation that emerged from this review is that similar patterns of connectivity changes are observed across studies regardless of TMS parameters. Though promising, we stress that these imaging findings must be evaluated cautiously given the widespread reliance on m...Continue Reading

References

Oct 1, 1990·The American Journal of Psychiatry·J L MartinotA Syrota
Feb 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·S E Starkstein, R G Robinson
Aug 24, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·F A KozelM S George
Nov 18, 2000·Biological Psychiatry·M S GeorgeJ C Ballenger
Dec 19, 2001·The Journal of Neuropsychiatry and Clinical Neurosciences·Z NahasM S George
Dec 13, 2002·Experimental Brain Research·Hartwig Roman Siebner, John Rothwell
Mar 8, 2005·Neuron·Helen S MaybergSidney H Kennedy
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Nov 13, 2007·Psychiatry Research·Oliver PogarellFrank Padberg
Apr 11, 2008·Annals of the New York Academy of Sciences·Randy L BucknerDaniel L Schacter
Aug 16, 2008·CNS Spectrums·Wayne C DrevetsMichael Trimble
May 5, 2009·Experimental Neurology·Frank Padberg, Mark S George
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yvette I ShelineMark A Mintun
Aug 25, 2010·Depression and Anxiety·Paul E HoltzheimerCharles M Epstein
Nov 26, 2010·Cognitive, Affective & Behavioral Neuroscience·Rebecca E CooneyIan H Gotlib
Jul 20, 2011·Human Brain Mapping·R Cameron CraddockHelen S Mayberg
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Mark C EldaiefAlvaro Pascual-Leone
Sep 15, 2012·Brain Stimulation·Jonathan Downar, Z Jeff Daskalakis

❮ Previous
Next ❯

Citations

Jun 25, 2019·The American Journal of Psychiatry·Noah S PhilipMascha van 't Wout-Frank
Feb 14, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Neir EshelAmit Etkin
Dec 4, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nicholas J PetrosinoNoah S Philip
Sep 23, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaolei XuBenjamin Becker
Jul 29, 2020·European Archives of Psychiatry and Clinical Neuroscience·Amin ZandvakiliNoah S Philip
May 26, 2020·European Archives of Psychiatry and Clinical Neuroscience·Igor FilipčićŽarko Bajić
Jul 11, 2020·European Archives of Psychiatry and Clinical Neuroscience·M DeppeM Schecklmann
Feb 6, 2020·The American Journal of Psychiatry·Tyler S KasterDaniel M Blumberger
Jul 10, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Wiebke StruckmannRobert Bodén
Aug 4, 2020·The American Journal of Psychiatry·Linda L Carpenter, Noah S Philip
Nov 12, 2020·Frontiers in Cellular Neuroscience·Matthew K HoganPhilip J Horner
Mar 3, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Jennifer BarredoNoah S Philip
May 14, 2021·Movement Disorders Clinical Practice·Pedro J Garcia Ruiz
Aug 20, 2021·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Shinsuke KoikeYoji Hirano
Oct 30, 2021·The American Journal of Psychiatry·Eleanor J ColeNolan R Williams
Dec 3, 2021·The American Journal of Psychiatry·Susan K Conroy, Paul E Holtzheimer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.