Neuroimaging of Freezing of Gait

Journal of Parkinson's Disease
Alfonso FasanoNicolaas I Bohnen

Abstract

Functional brain imaging techniques appear ideally suited to explore the pathophysiology of freezing of gait (FOG). In the last two decades, techniques based on magnetic resonance or nuclear medicine imaging have found a number of structural changes and functional disconnections between subcortical and cortical regions of the locomotor network in patients with FOG. FOG seems to be related in part to disruptions in the "executive-attention" network along with regional tissue loss including the premotor area, inferior frontal gyrus, precentral gyrus, the parietal and occipital areas involved in visuospatial functions of the right hemisphere. Several subcortical structures have been also involved in the etiology of FOG, principally the caudate nucleus and the locomotor centers in the brainstem. Maladaptive neural compensation may present transiently in the presence of acute conflicting motor, cognitive or emotional stimulus processing, thus causing acute network overload and resulting in episodic impairment of stepping.In this review we will summarize the state of the art of neuroimaging research for FOG. We will also discuss the limitations of current approaches and delineate the next steps of neuroimaging research to unravel the...Continue Reading

References

Jan 1, 1992·Stereotactic and Functional Neurosurgery·R P IaconoM Hoehn
Feb 1, 1983·Behavioural Brain Research·E T RollsS P Maddison
Jun 13, 1997·Neuroscience Letters·H FukuyamaH Shibasaki
Nov 14, 1997·Brain Injury : [BI]·S AggarwalD Jimenez
Aug 1, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·N FabreO Rascol
Mar 11, 1999·Annals of Neurology·T HanakawaH Shibasaki
Jun 23, 2000·Behavioural Brain Research·R de la Fuente-FernándezA J Stoessl
Jun 27, 2001·Neurology·N GiladiUNKNOWN Parkinson Study Group
Oct 2, 2003·Acta Neurochirurgica. Supplement·C C LeeF C Zhou
Sep 17, 2004·Movement Disorders : Official Journal of the Movement Disorder Society·Sun J ChungMyoung C Lee
Jul 12, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Hideaki MatsuiMasakuni Kameyama
Oct 27, 2005·Movement Disorders : Official Journal of the Movement Disorder Society·Mordechai LorberboymRuth Djaldetti
May 25, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Anna L BartelsKlaus L Leenders
Jun 27, 2006·Journal of the Neurological Sciences·Abraham Lieberman
Aug 23, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Chul Hyoung LyooMyung Sik Lee
Aug 29, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Yaroslau ComptaJosep Valls-Solé
Sep 4, 2007·Brain Research Reviews·Kaoru Takakusaki
Dec 11, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Francisco Coria, María del Puig Cozar-Santiago
Aug 1, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Anna L Bartels, Klaus L Leenders
Aug 19, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Alfonso FasanoAnna Rita Bentivoglio
Oct 28, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Hee K ParkMyoung C Lee
Feb 24, 2009·Lancet Neurology·David R Williams, Andrew J Lees
Apr 20, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sharon L Naismith, Simon J G Lewis
Aug 24, 2010·Neuroreport·Patrick M SchwederTipu Z Aziz
Oct 12, 2010·Neuroreport·Patrick M SchwederTipu Z Aziz
Dec 4, 2010·Brain : a Journal of Neurology·Anke H SnijdersIvan Toni
Dec 21, 2010·Journal of the Neurological Sciences·Hee Kyung ParkKwang-Kuk Kim
Jul 5, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·J M ShineS J G Lewis
Jan 31, 2012·British Journal of Clinical Pharmacology·Thuy C VuNicholas H G Holford
Feb 14, 2012·Acta Neurologica Scandinavica·K ImamuraT Nagatsu
Jan 1, 2011·Brain Connectivity·Karl J Friston
Mar 31, 2012·Parkinsonism & Related Disorders·Alfonso FasanoFrancesca Morgante
Apr 11, 2012·Movement Disorders : Official Journal of the Movement Disorder Society·Rajal G CohenJohn G Nutt
Apr 19, 2012·Parkinsonism & Related Disorders·Alessandro TessitorePaolo Barone
Apr 28, 2012·AJNR. American Journal of Neuroradiology·A TessitoreG Tedeschi

❮ Previous
Next ❯

Citations

Jan 17, 2016·Neuroscience and Biobehavioral Reviews·Samuel StuartLynn Rochester
Oct 16, 2015·Journal of Neurology·Courtney C WaltonSimon J G Lewis
Jul 26, 2015·Aging Clinical and Experimental Research·Taylor ChomiakBin Hu
Feb 16, 2017·Neurorehabilitation and Neural Repair·Vera GramignaAldo Quattrone
Sep 12, 2015·Human Brain Mapping·Elisa CanuMassimo Filippi
Dec 23, 2016·Annals of Neurology·Alfonso FasanoMichael D Fox
Feb 24, 2017·Scientific Reports·Andrea Cristina de Lima-PardiniEdson Amaro
Feb 15, 2018·Brain : a Journal of Neurology·Kaylena A Ehgoetz MartensJames M Shine
Sep 21, 2017·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Miroslav VastikPetr Kanovsky
Aug 29, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Kaylena A Ehgoetz MartensSimon J G Lewis
Sep 28, 2017·BMJ Case Reports·Kazuyuki NodaTakuji Yamamoto
Mar 26, 2019·JAMA Neurology·Jorik NonnekesBastiaan R Bloem
May 18, 2019·Brain : a Journal of Neurology·Daniel T CorpMichael D Fox
May 26, 2018·NPJ Parkinson's Disease·Courtney C WaltonSimon J G Lewis
Nov 7, 2019·Neurorehabilitation and Neural Repair·Ya-Yun LeeBeth E Fisher
Sep 14, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Brent BluettIrene Litvan
Jun 28, 2020·Nature Reviews. Neurology·Colleen G CanningMoran Gilat
Apr 17, 2020·Acta Neurologica Scandinavica·Aline Souza PagnussatAna Francisca Rozin Kleiner
Sep 15, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Jin Ho JungPhil Hyu Lee
Feb 19, 2016·Physiology·D S Peterson, F B Horak
Oct 28, 2019·Acta neurologica Belgica·Tülin AktürkSelçuk Çomoğlu
Mar 3, 2020·Journal of Parkinson's Disease·Stephen R LordEmily J Henderson
Apr 7, 2020·Neurorehabilitation and Neural Repair·Laurie A KingFay B Horak
Mar 1, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Marjan Jahanshahi, John C Rothwell
May 11, 2019·Brain and Behavior·Giovanni PalermoRoberto Ceravolo
Nov 2, 2019·Journal of Neural Transmission·Diego Santos-GarcíaUNKNOWN COPPADIS Study Group
Nov 13, 2017·Journal of Neurology·Sara PietracupaPatrizia Pantano
Oct 28, 2019·Brain : a Journal of Neurology·Daniel WeissSimon J G Lewis
Nov 6, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Nicoló Gabriele PozziClaudio Pacchetti
Dec 9, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Tony SzturmJi Hyun Ko
Nov 27, 2020·Frontiers in Neurology·J Sebastian MarquezOu Bai
Dec 5, 2019·NeuroImage. Clinical·Komal BhartiPatrizia Pantano

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
SMA

Software Mentioned

fMRI
RS

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.