Neuroimaging of pediatric infratentorial tumors and the value of diffusion-weighted imaging (DWI) in determining tumor grade.

Acta Radiologica
Kirthi SathyakumarGeeta Chacko

Abstract

Diffusion-weighted imaging (DWI) provides information about the cellular density of tumors. This feature is useful in grading and identifying different tumor types. To assess the value of diffusion restriction and apparent diffusion coefficient (ADC) values in differentiating pediatric infratentorial tumors. This was a retrospective review of the magnetic resonance imaging (MRI) of 82 children (age range 1-16 years) with infratentorial tumors. Histopathological grading after surgical excision/biopsy was categorized as low grade (WHO grades I and II) (n = 31; 29 pilocytic astrocytomas, 2 ependymomas) and high grade (WHO grade III and IV) (n = 51; 40 medulloblastomas, 8 anaplastic ependymomas, 1 anaplastic astrocytoma, 2 atypical rhabdoid teratoid tumors [ATRT]). MRI features and ADC values were compared among tumor types and grades using a two-tailed t test, Mann-Whitney U test for continuous data and Chi-square test for categorical variables. Diffusion restriction and low ADC value was a feature of high-grade tumors (P<0.001). The mean ADC values of the low-grade and high-grade tumors were 1.567 × 10-3mm2/s and 0.661 × 10-3mm2/s, respectively. Using 0.9 × 10-3mm2/s as the cut-off value, the sensitivity, specificity, positive an...Continue Reading

References

May 16, 2002·Neuroradiology·K OkamotoK Sakai
Aug 18, 2004·Toxicology and Applied Pharmacology·Rachel Tobias Baldwin, Susan Preston-Martin
Oct 6, 2006·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Peter KanJohn R W Kestle
Oct 20, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Riyadh N Al-OkailiElias R Melhem
Feb 24, 2007·Journal of Neuroradiology. Journal De Neuroradiologie·J F SchneiderN Girard
Dec 10, 2009·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Majda M Thurnher
Jun 12, 2010·AJNR. American Journal of Neuroradiology·J L JaremkoM R Ditchfield
Oct 13, 2011·Journal of Magnetic Resonance Imaging : JMRI·Andrea PorettiThierry A G M Huisman
Aug 14, 2013·Pediatric Blood & Cancer·Andrea PorettiThierry A G M Huisman
Feb 28, 2014·The Neuroradiology Journal·Theodore Thomas Pierce, James M Provenzale
Sep 10, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Patryk SkowronMichael D Taylor

❮ Previous
Next ❯

Citations

Jul 17, 2021·AJNR. American Journal of Neuroradiology·M ZhangK W Yeom

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Peter KanJohn R W Kestle
Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society
Mahsa Raisi-NafchiJalal Jalal-Shokouhi
© 2022 Meta ULC. All rights reserved