Neuroimaging of Subacute Brain Inflammation and Microstructural Changes Predicts Long-Term Functional Outcome after Experimental Traumatic Brain Injury

Journal of Neurotrauma
Stephan MissaultStefanie Dedeurwaerdere

Abstract

There is currently a lack of prognostic biomarkers to predict the different sequelae following traumatic brain injury (TBI). The present study investigated the hypothesis that subacute neuroinflammation and microstructural changes correlate with chronic TBI deficits. Rats were subjected to controlled cortical impact (CCI) injury, sham surgery, or skin incision (naïve). CCI-injured (n = 18) and sham-operated rats (n = 6) underwent positron emission tomography (PET) imaging with the translocator protein 18 kDa (TSPO) radioligand [18F]PBR111 and diffusion tensor imaging (DTI) in the subacute phase (≤3 weeks post-injury) to quantify inflammation and microstructural alterations. CCI-injured, sham-operated, and naïve rats (n = 8) underwent behavioral testing in the chronic phase (5.5-10 months post-injury): open field and sucrose preference tests, two one-week video-electroencephalogram (vEEG) monitoring periods, pentylenetetrazole (PTZ) seizure susceptibility tests, and a Morris water maze (MWM) test. In vivo imaging revealed pronounced neuroinflammation, decreased fractional anisotropy, and increased diffusivity in perilesional cortex and ipsilesional hippocampus of CCI-injured rats. Behavioral analysis revealed disinhibition, anhe...Continue Reading

References

Apr 1, 1997·IEEE Transactions on Medical Imaging·M DefriseD F Newport
Mar 23, 2007·Journal of Neurotrauma·Andrew I R MaasEwout W Steyerberg
Dec 7, 2007·Brain : a Journal of Neurology·Irina KharatishviliAsla Pitkänen
Jan 1, 1994·IEEE Transactions on Medical Imaging·H M Hudson, R S Larkin
Feb 14, 2008·BMJ : British Medical Journal·UNKNOWN MRC CRASH Trial CollaboratorsSurakrant Yutthakasemsunt
Aug 8, 2008·PLoS Medicine·Neil H Young, Peter J D Andrews
Nov 18, 2008·Experimental Neurology·Robert F HuntBret N Smith
Dec 9, 2008·Journal of Neurotrauma·Nigel C JonesTerence J O'Brien
Mar 26, 2009·Journal of Neurotrauma·Cody A ChastainKaren A Tong
Jan 14, 2010·Journal of Neurotrauma·Katelyn C S McNamaraJonathan Lifshitz
Dec 31, 2010·Journal of Neurotrauma·Jeffrey T ColeWilliam D Watson
Aug 20, 2011·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Thomas BourdierAndrew Katsifis
Oct 20, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·David R OwenJustin P Rubio
Apr 5, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Romina MizrahiSylvain Houle
Feb 28, 2013·Nature Reviews. Neurology·Bob RoozenbeekDavid K Menon
Mar 9, 2013·Journal of Neurotrauma·Riikka ImmonenAsla Pitkänen
May 30, 2013·PloS One·Shiyang WangQuan Jiang
Mar 5, 2014·The Journal of Head Trauma Rehabilitation·Shannon B JuengstAmy Kathleen Wagner
Mar 13, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Yu WangXiaoyuan Chen
Nov 11, 2014·Journal of Neuropathology and Experimental Neurology·Tsang-Wei TuJoseph A Frank
Mar 4, 2015·Current Opinion in Neurology·Robert S Fisher
Mar 15, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Chul Hyoung LyooWilliam Charles Kreisl

❮ Previous
Next ❯

Citations

Jun 18, 2020·Nature Reviews. Neurology·Gary P Brennan, David C Henshall
Jun 14, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Viviane Bouilleret, Stefanie Dedeurwaerdere
Jul 13, 2021·Infection and Immunity·Julian L GoggiLaurent Renia

❮ Previous
Next ❯

Software Mentioned

Paravision
PMOD
NeuroScore
ImageJ
MATLAB
EthoVision XT
SPM12
EthoVision
JMP Pro
Amira

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.