Neuroimmunology of the paraneoplastic neurological degenerations

Current Opinion in Immunology
Wendy K Roberts, Robert B Darnell

Abstract

The paraneoplastic neurological degenerations (PNDs) are remarkable examples of naturally occurring tumor immunity in humans. In PND patients, common tumors such as breast, ovarian and lung tumors express proteins normally made exclusively in the brain, eliciting an immune response that successfully suppresses growth of the tumor. This successful anti-tumor response would be expected to go clinically unnoticed by the patient, but the immune cells mediating the response somehow cross into the brain, resulting in an autoimmune attack on neurons and neurological symptoms. Pieces of the mystery of this tumor immune response and neuronal autoimmunity have been assembled, but much more needs to be learned.

References

May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·R B Darnell
Nov 11, 1998·Nature Medicine·M L AlbertR B Darnell
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·J D Keene
Jun 6, 2000·Neuron·M H ButlerM Solimena
Sep 20, 2000·The Journal of Experimental Medicine·T BrabbJ Goverman
Apr 6, 2001·Cellular and Molecular Life Sciences : CMLS·C M Brennan, J A Steitz
Jul 24, 2003·Nature Reviews. Immunology·Richard M RansohoffGrahame Kidd
Oct 17, 2003·The New England Journal of Medicine·Robert B Darnell, Jerome B Posner
May 4, 2004·Annals of Neurology·Pia KivisäkkRichard M Ransohoff
May 18, 2004·Nature Immunology·Antoine PerchelletJoan Goverman

❮ Previous
Next ❯

Citations

Jan 24, 2006·Cancer Immunology, Immunotherapy : CII·Anette KnudsenChristian A Vedeler
Jul 28, 2007·Cancer Immunology, Immunotherapy : CII·Sissel E MonstadChristian A Vedeler
Jul 22, 2009·Current Opinion in Oncology·Adrien Didelot, Jérôme Honnorat
Jun 2, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·O Stich, S Rauer
Jun 11, 2009·The Journal of Clinical Investigation·Wendy K RobertsRobert B Darnell
May 8, 2007·Orphanet Journal of Rare Diseases·Jérôme Honnorat, Jean-Christophe Antoine
Oct 16, 2010·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Robert B Darnell
Jun 30, 2012·Molecular Biology International·Jennifer LawShairaz Baksh
Oct 25, 2014·Acta Neuropathologica·Manja SchubertChristian A Vedeler
Mar 14, 2009·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Anette Storstein, Christian A Vedeler
Oct 6, 2007·Scandinavian Journal of Gastroenterology·Hans TörnblomGreger Lindberg
Oct 4, 2005·Expert Opinion on Biological Therapy·Edward J Dropcho
Oct 4, 2011·Current Opinion in Neurobiology·Birgitte Rahbek KornumEmmanuel Mignot
Sep 6, 2011·Progress in Neurobiology·Minesh Kapadia, Boris Sakic
Jun 30, 2009·Revue neurologique·J Honnorat
Feb 10, 2007·Autoimmunity Reviews·Lorenzo LorussoGiovanni Ricevuti
May 11, 2005·Immunological Reviews·Marc E WekslerPaul Szabo
Sep 25, 2008·International Journal of Cancer. Journal International Du Cancer·Alexandr V BazhinStefan B Eichmüller
Feb 8, 2006·Annals of the New York Academy of Sciences·Wei D Duan-PorterAntony Rosen
Mar 18, 2006·Clinical and Experimental Immunology·S E MonstadC A Vedeler
Jul 8, 2011·Acta Neurologica Scandinavica. Supplementum·M RaspotnigA Storstein
Jun 21, 2012·Acta Neurologica Scandinavica·F Asztely, E Kumlien
Mar 24, 2016·Biochemical and Biophysical Research Communications·Yong Hoi LeeKuan Onn Tan
Sep 3, 2004·Current Opinion in Immunology·Frank L Heppner, Adriano Aguzzi
Aug 1, 2015·Annals of Neurology·Wendy K RobertsRobert B Darnell
Oct 4, 2006·Neuron·Donny D Licatalosi, Robert B Darnell
May 3, 2011·Blood·Sally M AmosMichael H Kershaw
Jun 16, 2016·Epilepsy & Behavior : E&B·Anna SerafiniShasha Wu
Mar 6, 2007·Journal of Neuroimmunology·Cecilie TotlandChristian Vedeler
Apr 22, 2018·Neuropathology and Applied Neurobiology·D PanjaM Schubert
Jun 30, 2007·Molekuliarnaia genetika, mikrobiologiia i virusologiia·P V BelousovD V Kuprash
Jan 10, 2009·The Neurologist·Thomas B Toothaker, Michael Rubin
Jun 30, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Robin Grant, Francesc Graus
Jun 13, 2012·Internal Medicine·Yayoi ShimazuAkifumi Takaori-Kondo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.