Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models.

Journal of Neuroinflammation
Michiyo IbaEliezer Masliah

Abstract

α-Synuclein (α-syn) is a pre-synaptic protein which progressively accumulates in neuronal and non-neuronal cells in neurodegenerative diseases such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy. Recent evidence suggests that aberrant immune activation may be involved in neurodegeneration in PD/DLB. While previous studies have often focused on the microglial responses, less is known about the role of the peripheral immune system in these disorders. To understand the involvement of the peripheral immune system in PD/DLB, we evaluated T cell populations in the brains of α-syn transgenic (tg) mice (e.g., Thy1 promoter line 61) and DLB patients. Immunohistochemical analysis showed perivascular and parenchymal infiltration by CD3+/CD4+ helper T cells, but not cytotoxic T cells (CD3+/CD8+) or B cells (CD20+), in the neocortex, hippocampus, and striatum of α-syn tg mice. CD3+ cells were found in close proximity to the processes of activated astroglia, particularly in areas of the brain with significant astrogliosis, microgliosis, and expression of pro-inflammatory cytokines. In addition, a subset of CD3+ cells co-expressed interferon γ. Flow cytometric analysis of immune cells in the brains o...Continue Reading

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Citations

Feb 13, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Tai WangYuming Xu
Feb 14, 2021·Journal of Parkinson's Disease·Sonia GeorgePatrik Brundin
Dec 5, 2020·Acta Neuropathologica Communications·Antonina KouliCaroline H Williams-Gray
Jun 24, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Dallin Dressman, Wassim Elyaman
Apr 16, 2021·Brain : a Journal of Neurology·Qing WangSven Pettersson
Oct 15, 2021·Science·David GateTony Wyss-Coray

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Methods Mentioned

BETA
transgenic
flow cytometry
FACS
light microscopy
flow
confocal microscopy

Software Mentioned

Zen
FlowJo
Image Quant

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