Neuroinflammation is increased in the parietal cortex of atypical Alzheimer's disease

Journal of Neuroinflammation
Baayla D C BoonFemke H Bouwman

Abstract

While most patients with Alzheimer's disease (AD) present with memory complaints, 30% of patients with early disease onset present with non-amnestic symptoms. This atypical presentation is thought to be caused by a different spreading of neurofibrillary tangles (NFT) than originally proposed by Braak and Braak. Recent studies suggest a prominent role for neuroinflammation in the spreading of tau pathology. We aimed to explore whether an atypical spreading of pathology in AD is associated with an atypical distribution of neuroinflammation. Typical and atypical AD cases were selected based on both NFT distribution and amnestic or non-amnestic clinical presentation. Immunohistochemistry was performed on the temporal pole and superior parietal lobe of 10 typical and 9 atypical AD cases. The presence of amyloid-beta (N-terminal; IC16), pTau (AT8), reactive astrocytes (GFAP), microglia (Iba1, CD68, and HLA-DP/DQ/DR), and complement factors (C1q, C3d, C4b, and C5b-9) was quantified by image analysis. Differences in lobar distribution patterns of immunoreactivity were statistically assessed using a linear mixed model. We found a temporal dominant distribution for amyloid-beta, GFAP, and Iba1 in both typical and atypical AD. Distributio...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Dec 15, 1989·Neuroscience Letters·P L McGeerE G McGeer
Jan 1, 1982·Acta Neuropathologica·P Eikelenboom, F C Stam
Jan 19, 1999·Archives of General Psychiatry·W J HoogendijkD F Swaab
May 5, 2000·Neurobiology of Aging·Y M ArendsJ J Hauw
Jun 20, 2000·Neurobiology of Aging·H AkiyamaT Wyss-Coray
Jul 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tony Wyss-CorayEliezer Masliah
Jun 9, 2005·Alzheimer Disease and Associated Disorders·H ZanjaniJ L Price
Apr 22, 2009·Acta Neuropathologica·Charles DuyckaertsMarie-Claude Potier
Jan 12, 2010·Journal of Alzheimer's Disease : JAD·Esther L G E KoedamYolande A L Pijnenburg
Oct 6, 2010·Neuron·Kiran BhaskarBruce T Lamb
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
Jun 28, 2011·Brain : a Journal of Neurology·Leonardo Cruz de SouzaMarie Sarazin
Dec 14, 2011·Journal of Neuroinflammation·Jeroen J M HoozemansWillem A van Gool
Jan 24, 2012·Lancet Neurology·Sebastian J CrutchNick C Fox
Oct 15, 2013·Translational Neurodegeneration·Yong ShenRena Li
May 23, 2014·Lancet Neurology·Bruno DuboisJeffrey L Cummings
Dec 30, 2014·Dementia and Geriatric Cognitive Disorders Extra·Emilie BeaufilsCaroline Hommet
Apr 3, 2015·Brain : a Journal of Neurology·Nicole MaphisKiran Bhaskar
Aug 12, 2015·Human Brain Mapping·Rik OssenkoppeleGil D Rabinovici
Oct 6, 2015·Nature Neuroscience·Hirohide AsaiTsuneya Ikezu
Dec 8, 2015·Journal of Alzheimer's Disease : JAD·Marta BolósJesús Avila
Mar 11, 2016·Brain : a Journal of Neurology·Rik OssenkoppeleGil D Rabinovici
Oct 4, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Heather M SnyderMaria C Carrillo
Oct 30, 2016·Acta Neuropathologica Communications·Jonathan D CherryThor D Stein
Mar 8, 2017·Journal of Neural Transmission·Lauren WalkerJohannes Attems
Jun 2, 2017·Science Translational Medicine·Qiaoqiao ShiCynthia A Lemere

❮ Previous
Next ❯

Citations

Oct 18, 2018·Molecular Nutrition & Food Research·Menglian LvZhongxiao Wan
Jul 7, 2019·Acta Neuropathologica Communications·Thomas VogelsTomáš Hromádka
Sep 15, 2020·Acta Neuropathologica·Baayla D C BoonJeroen J M Hoozemans
Feb 21, 2021·Lancet Neurology·Jonathan Graff-RadfordMelissa E Murray
Jul 21, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Rong-Rong ZhangShi-Jie Zhang
Apr 16, 2021·Molecular Psychiatry·Giulia Cisbani, Serge Rivest
Sep 15, 2021·ACS Chemical Neuroscience·Soumya MukherjeeColin L Masters
Jul 13, 2019·Environmental Research·Lilian Calderón-GarcidueñasAngélica González-Maciel

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA

Software Mentioned

SPSS
ImageJ

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.