Neuroinflammatory changes increase the impact of stressors on neuronal function

Biochemical Society Transactions
Alessia Piazza, Marina A Lynch

Abstract

In the last few years, several research groups have reported that neuroinflammation is one feature common to several neurodegenerative diseases and that similar, although perhaps less profound, neuroinflammatory changes also occur with age. Age is the greatest risk factor in many neurodegenerative diseases, and the possibility exists that the underlying age-related neuroinflammation may contribute to this increased risk. Several animal models have been used to examine this possibility, and it is now accepted that, under experimental conditions in which microglial activation is up-regulated, responses to stressors are exacerbated. In the present article, these findings are discussed and data are presented from in vitro and in vivo experiments which reveal that responses to Abeta (amyloid beta-peptide) are markedly up-regulated in the presence of LPS (lipopolysaccharide). These, and previous findings, point to a vulnerability associated with inflammation and suggest that, even though inflammation may not be the primary cause of neurodegenerative disease, its treatment may decelerate disease progression.

References

Jun 11, 1999·The American Journal of Pathology·M StalderM Jucker
Dec 10, 1999·Neurobiology of Aging·B Hauss-WegrzyniakG L Wenk
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·V T Nguyen, E N Benveniste
Jan 5, 2002·Neurobiology of Aging·P L McGeer, E G McGeer
May 20, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·C HolmesV H Perry
Jul 10, 2003·Lancet Neurology·Gianvito MartinoMassimo Filippi
Jan 13, 2004·Physiological Reviews·M A Lynch
Jan 27, 2004·Journal of Neuroimmunology·J P Godbout, R W Johnson
Oct 12, 2004·The International Journal of Biochemistry & Cell Biology·Ehab E Tuppo, Hugo R Arias
May 4, 2005·FEMS Immunology and Medical Microbiology·Clive WellerIngvar T Bjarnason
May 17, 2005·Neurobiology of Aging·Ruth M BarrientosSteven F Maier
Aug 6, 2005·Progress in Neurobiology·Michelle L Block, Jau-Shyong Hong
Oct 22, 2005·Annals of Neurology·Honglei ChenAlberto Ascherio
Nov 26, 2005·Neurobiology of Aging·Daniela GalimbertiElio Scarpini
Mar 25, 2006·Journal of Alzheimer's Disease : JAD·Robert E Mrak, W Sue T Griffin
May 3, 2006·Journal of Neuropathology and Experimental Neurology·Jessica R Conde, Wolfgang J Streit
May 23, 2006·Neurobiology of Aging·Aileen M LynchMarina A Lynch
Jul 28, 2006·Neurology·Jorge CorrealeWendy Gilmore
Sep 19, 2006·Nature Reviews. Microbiology·Adriano Aguzzi, Mathias Heikenwalder
Sep 20, 2006·Journal of Neurochemistry·Rebecca GriffinMarina A Lynch
Dec 19, 2006·Neurobiology of Aging·J AbrahamR W Johnson
Jan 26, 2007·Journal of Neurochemistry·Anthony LyonsMarina A Lynch
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony LyonsMarina A Lynch
Aug 7, 2007·International Review of Neurobiology·Ashley ReynoldsHoward E Gendelman
Aug 23, 2007·Journal of Neurochemistry·Aedín M MinogueMarina A Lynch
Nov 6, 2007·The Journal of Biological Chemistry·Rachael M ClarkeMarina A Lynch
Dec 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jonathan P GodboutRodney W Johnson
Mar 29, 2008·Antioxidants & Redox Signaling·Mauro CozzolinoMaria Teresa Carrì
Jul 19, 2008·Neuron Glia Biology·Kelly R Miller, Wolfgang J Streit

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Citations

Jul 25, 2009·Molecular Neurobiology·Marina A Lynch
Jun 30, 2010·Expert Reviews in Molecular Medicine·David J BondaHyoung-gon Lee
Jan 15, 2010·International Journal of Radiation Biology·Yutong HaoZhengping Yu
Dec 3, 2014·Neurotoxicology and Teratology·Brenna M FlanneryPamela J Lein
Nov 30, 2010·Neurochemistry International·Kevin J MurphyMarina A Lynch
Feb 16, 2010·Journal of Neuroscience Research·Irina BurdMichal A Elovitz
Jan 12, 2010·Neuropathology and Applied Neurobiology·D J BondaH-G Lee
Jan 16, 2009·Biochemical Society Transactions·Adrienne M Gorman, Karen M Doyle

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