Neuroinflammatory Gene Expression Alterations in Anterior Cingulate Cortical White and Gray Matter of Males With Autism Spectrum Disorder.

Autism Research : Official Journal of the International Society for Autism Research
Aubrey N SciaraMichelle J Chandley

Abstract

Evidence for putative pathophysiological mechanisms of autism spectrum disorder (ASD), including peripheral inflammation, blood-brain barrier disruption, white matter alterations, and abnormal synaptic overgrowth, indicate a possible involvement of neuroinflammation in the disorder. Neuroinflammation plays a role in the development and maintenance of the dendritic spines involved in glutamatergic and GABAergic neurotransmission, and also influences blood-brain permeability. Cytokines released from microglia can impact the length, location or organization of dendritic spines on excitatory and inhibitory cells as well as recruit and impact glial cell function around the neurons. In this study, gene expression levels of anti- and pro-inflammatory signaling molecules, as well as oligodendrocyte and astrocyte marker proteins, were measured in both gray and white matter tissue in the anterior cingulate cortex from ASD and age-matched typically developing (TD) control brain donors, ranging from ages 4 to 37 years. Expression levels of the pro-inflammatory gene, HLA-DR, were significantly reduced in gray matter and expression levels of the anti-inflammatory gene MRC1 were significantly elevated in white matter from ASD donors as compar...Continue Reading

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Citations

Jan 29, 2021·Frontiers in Behavioral Neuroscience·Nelva T QuezadaEsteban E Aliaga
Jul 27, 2021·Neuroscience and Biobehavioral Reviews·Chrystiane V A ToscanoJoana M Gaspar

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Methods Mentioned

BETA
chip
PCR
fluorescence activated cell sorting

Software Mentioned

SPSS
GraphPad Prism

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