Neuroinvasion and Viral Reservoir in COVID-19

Curēus
Marcos Altable Pérez, Juan Moises De la Serna

Abstract

The new coronavirus disease 2019 (COVID-19) has a remarkably high transmissibility potential and sometimes invades the central nervous system (CNS). The study of the involvement of the nervous system in the pathogenesis of the disease is especially interesting. Currently, there are only three main theories about it: direct neuroinvasion; blood-brain barrier (BBB) crossing and nicotinic hypothesis. Because of the rapid expansion of a virus that until now was unknown, it is necessary to know the mechanisms by which severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) generates the disease. The study of the involvement of the nervous system in the pathogenesis of the disease is especially interesting, since it is the least studied question with more innovative theories that could explain not only neurological complications, but also the primary infection and the involvement of the various organs and systems.

References

Dec 22, 1999·Journal of Neuropathology and Experimental Neurology·E LaviL Fu
Mar 30, 2007·The American Journal of Pathology·Jiang Gu, Christine Korteweg
Jul 8, 2008·Nature Reviews. Microbiology·Kwang Sik Kim
May 17, 2011·Journal of Neuropathology and Experimental Neurology·Kenneth S ShindlerJayasri Das Sarma
Oct 5, 2013·Clinical Microbiology Reviews·Anne A Gershon, Michael D Gershon
Nov 5, 2016·Nature Reviews. Neuroscience·Katelyn D MillerGlenn F Rall
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos
Jun 17, 2018·Journal for Immunotherapy of Cancer·Alexander Shimabukuro-VornhagenMichael S von Bergwelt-Baildon
Aug 9, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joshua M OakesXinping Yue
Feb 1, 2020·The New England Journal of Medicine·Michelle L HolshueUNKNOWN Washington State 2019-nCoV Case Investigation Team
Feb 28, 2020·Journal of Medical Virology·Yan-Chao LiTsutomu Hashikawa
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 15, 2020·Journal of Medical Virology·Feng HeWeina Li
Mar 17, 2020·The Journal of Infection·Guangming YeXinghuan Wang
Apr 1, 2020·Nature·Jian ShangFang Li
Apr 3, 2020·Brain, Behavior, and Immunity·Yeshun WuChun Yang
Apr 9, 2020·CNS Neuroscience & Therapeutics·Abdul Mannan Baig
Apr 18, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·J Matías-GuiuJ A Matias-Guiu
Apr 23, 2020·Transboundary and Emerging Diseases·Kevin Roe
Apr 25, 2020·Revista de neurologia·F J Carod-Artal
May 2, 2020·Eye and Vision·Hua-Tao XieMing-Chang Zhang
May 5, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·P J Serrano-CastroF Rodríguez de Fonseca

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.