Neurokinin-1 (NK-1) receptor is required in Clostridium difficile- induced enteritis

The Journal of Clinical Investigation
I CastagliuoloC Pothoulakis

Abstract

Toxin A, a 308,000-Mr enterotoxin from Clostridium difficile, mediates antibiotic-associated diarrhea and colitis in humans. Injection of toxin A into animal intestine triggers an acute inflammatory response characterized by activation of sensory neurons and immune cells of the intestinal lamina propria, including mast cells and macrophages, and migration of circulating neutrophils in the involved intestinal segment. In this study we show that mice genetically deficient in the neurokinin-1 receptor are protected from the secretory and inflammatory changes as well as from epithelial cell damage induced by toxin A. The protective effect of neurokinin-1R deletion correlates with diminished intestinal levels of the cytokine TNF-alpha and its mRNA and the leukocyte enzyme myeloperoxidase. These results demonstrate a major requirement for substance P receptors in the pathogenesis of acute inflammatory diarrhea.

References

Dec 1, 1991·Pflügers Archiv : European journal of physiology·M Schemann, H Kayser
Jan 1, 1988·Life Sciences·H I Jacoby
Jul 21, 1971·Nature: New Biology·M M ChangH D Niall
Feb 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·C PothoulakisS E Leeman
May 1, 1995·The Journal of Clinical Investigation·M RieglerJ T LaMont
Mar 1, 1994·The Journal of Clinical Investigation·C P KellyC Pothoulakis
Jan 27, 1994·The New England Journal of Medicine·C P KellyJ T LaMont
Aug 1, 1996·The Journal of Clinical Investigation·C PothoulakisJ T LaMont
Sep 20, 1996·Science·C R BozicN P Gerard
Oct 1, 1996·Trends in Microbiology·C von Eichel-StreiberM Thelestam
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·I CastagliuoloC Pothoulakis

❮ Previous
Next ❯

Citations

Dec 23, 2003·Immunology Letters·Kerstin LangFrank Entschladen
Mar 18, 2004·Microbes and Infection·Lena SvenssonChristine Wennerås
Apr 15, 2004·Toxicology and Applied Pharmacology·Kalina Venkova, Beverley Greenwood-Van Meerveld
Aug 2, 2003·Gastroenterology·Tor C SavidgeCharalabos Pothoulakis
Dec 14, 2002·Brain, Behavior, and Immunity·Paul H Black
May 30, 2001·The International Journal of Biochemistry & Cell Biology·S Harrison, P Geppetti
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Martin BeinbornJoel V Weinstock
Oct 7, 2006·Current Opinion in Gastroenterology·C Okolo, C Surawicz
Oct 13, 2006·Current Opinion in Gastroenterology·C Pothoulakis
Oct 12, 2004·Inflammatory Bowel Diseases·Kristina A MatkowskyjRichard V Benya
Apr 18, 2007·Journal of Clinical Gastroenterology·Jackie D Wood
May 27, 2005·The Journal of Pharmacology and Experimental Therapeutics·Hon-Wai KoonCharalabos Pothoulakis
Mar 14, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kara GrossCharalabos Pothoulakis
Apr 3, 2003·The Journal of Clinical Investigation·Mara Chavolla-CalderónJ Julio Pérez Fontán
Mar 17, 1999·The Journal of Clinical Investigation·I CastagliuoloC Pothoulakis
Jul 1, 2010·Toxins·Xingmin SunHanping Feng
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·S SturialeS M Collins
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Iordanes KaragiannidesCharalabos Pothoulakis
Feb 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hon-Wai KoonCharalabos Pothoulakis
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Pauline M AntonCharalabos Pothoulakis
May 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Nigel W Bunnett
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·J P LaiS D Douglas
Feb 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Simos SimeonidisCharalabos Pothoulakis
Aug 22, 2007·The British Journal of Radiology·J Wang, M Hauer-Jensen
Sep 12, 2000·Current Gastroenterology Reports·C M Surawicz
Sep 7, 2007·Digestive Diseases and Sciences·A R F BarretoG A C Brito
Nov 4, 2000·Expert Opinion on Investigational Drugs·V LeroyN P Peet
Nov 7, 2015·Cellular and Molecular Gastroenterology and Hepatology·Aristea SideriCharalabos Pothoulakis
Apr 19, 2008·Journal of Cellular and Molecular Medicine·Madhav BhatiaShabbir M Moochhala
Jul 13, 2011·Journal of Cellular Biochemistry·Lixin KanJohn A Kessler
Mar 21, 2007·American Journal of Surgery·Christoph W MichalskiHelmut Friess

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.