Neurokinin 3 receptor immunoreactivity in the septal region, preoptic area and hypothalamus of the female sheep: colocalisation in neurokinin B cells of the arcuate nucleus but not in gonadotrophin-releasing hormone neurones.

Journal of Neuroendocrinology
Marcel AmstaldenMichael Lehman

Abstract

Recent evidence has implicated neurokinin B (NKB) in the complex neuronal network mediating the effects of gonadal steroids on the regulation of gonadotrophin-releasing hormone (GnRH) secretion. Because the neurokinin 3 receptor (NK3R) is considered to mediate the effects of NKB at the cellular level, we determined the distribution of immunoreactive NK3R in the septal region, preoptic area (POA) and hypothalamus of the ewe. NK3R cells and/or fibres were found in areas including the bed nucleus of the stria terminalis, POA, anterior hypothalamic and perifornical areas, dopaminergic A15 region, dorsomedial and lateral hypothalamus, arcuate nucleus (ARC) and the ventral premammillary nucleus. We also used dual-label immunocytochemistry to determine whether a neuroanatomical basis for direct modulation of GnRH neurones by NKB was evident. No GnRH neurones at any rostral-caudal level were observed to contain NK3R immunoreactivity, although GnRH neurones and fibres were in proximity to NK3R-containing fibres. Because NKB fibres formed close contacts with NKB neurones in the ARC, we determined whether these NKB neurones also contained immunoreactive NK3R. In luteal-phase ewes, 64% +/- 11 of NKB neurones colocalised NK3R. In summary, N...Continue Reading

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Citations

Jul 3, 2013·Nature Reviews. Endocrinology·Robert P Millar, Claire L Newton
Nov 4, 2010·American Journal of Physiology. Endocrinology and Metabolism·Víctor M NavarroRobert A Steiner
Sep 20, 2012·Endocrinology·Robert L Goodman, Michael N Lehman
Mar 20, 2010·Endocrine Reviews·Catherine A Christian, Suzanne M Moenter
Mar 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Víctor M NavarroManuel Tena-Sempere
Aug 31, 2014·General and Comparative Endocrinology·Guangfu HuAnderson O L Wong
Apr 24, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Hiroaki OkamuraYoshihiro Wakabayashi
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Feb 24, 2010·Molecular and Cellular Endocrinology·A Kemal Topaloglu
Jul 22, 2010·Journal of Neuroendocrinology·H OkamuraY Mori
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