PMID: 9183701Jun 9, 1997Paper

Neurokinin receptor mRNA localization in human midbrain dopamine neurons

The Journal of Comparative Neurology
C J WhittyM J Bannon

Abstract

The structurally related neurokinin peptides, substance P and neurokinin A, are found in abundance within the substantia nigra of a variety of mammalian species. Although it has been established recently that the neurokinin-3 (NK3) receptor is the predominant neurokinin receptor found in rat substantia nigra and adjacent midbrain nuclei, the nature of the neurokinin receptor expressed in human midbrain has not been elucidated. In the present study, neurokinin receptor messenger RNA (mRNA) content within rat and human midbrain were directly compared by using quantitative in situ hybridization histochemistry. In contrast to the high abundance of NK3 receptor mRNA within dopamine (DA) cells of the rat midbrain, neurokinin-1 (NK1), but not NK3, receptor mRNA was localized to human midbrain DA cells. Within the human midbrain, the abundance of NK1 receptor mRNA differed significantly among the distinct DA cell-containing nuclei, with the highest level of expression seen in several subdivisions of the substantia nigra. Thus different neurokinin receptor subtypes apparently mediate the effects of substance P and neurokinin A on human versus rat DA neurons.

Citations

Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael J BannonCarl J Schmidt
Nov 9, 2000·Clinical and Experimental Pharmacology & Physiology·P A TooneyL A Chahl
Jun 23, 2009·Neuropharmacology·Rebecca E NordquistWill Spooren
May 20, 2003·The European Journal of Neuroscience·Laura CaberlottoRenzo Carletti
Dec 13, 2012·Brain, Behavior, and Immunity·Beatriz Rodriguez-GrandeAdam Denes

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