Neuroleptic, antimuscarinic, and antiadrenergic activity of chlorpromazine, thioridazine, and their metabolites

Psychiatry Research
Bruce M CohenA Aoba


Chlorpromazine and thioridazine are widely used antipsychotic agents that are extensively metabolized. Parent compounds and metabolites have diverse pharmacologic activities, and differences in patterns of metabolism may explain differences in therapeutic and side effects from individual to individual. Radioreceptor assays were used to determine the neuroleptic, antimuscarinic, and anti-alpha-noradrenergic potency of chlorpromazine, thioridazine, and their metabolites. The results indicate that these metabolites show a wide range of potencies. The spectrum of activity of a metabolite may be quite different from that of its parent compound. The clinical relevance of these findings to individual differences in drug response is discussed. The combined use of radioreceptor assays and chemical assays in future clinical research is proposed.


Jan 1, 1983·Psychopharmacology·L Molander, L Borgström
Jan 1, 1980·Psychopharmacology·Bruce M CohenR I Altesman
Jan 1, 1982·Psychopharmacology·D JesteR J Wyatt
Nov 19, 1981·European Journal of Pharmacology·R D SturgeonH Y Meltzer
Jun 24, 1986·European Journal of Pharmacology·P A HalsS G Dahl
Jul 1, 1980·Neuropharmacology·Bruce M CohenR J Baldessarini
Jul 1, 1982·Neuropharmacology·A CampbellR J Baldessarini
May 1, 1980·Psychiatry Research·Bruce M CohenM Friedman
Jul 1, 1986·Archives of Gerontology and Geriatrics·A AobaK Hasegawa
Mar 14, 1991·The New England Journal of Medicine·R J Baldessarini, F R Frankenburg
May 10, 2005·The Proceedings of the Nutrition Society·Glenn Iason
Aug 26, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Babiker M El-HajHeyam S Ali
Jan 1, 1982·Acta Pharmacologica Et Toxicologica·M LinnoilaR J Wyatt
May 1, 1986·Annals of Clinical Biochemistry·J KrskaS D Soni


Feb 1, 1977·Archives of General Psychiatry·S H Snyder, H I Yamamura
Jul 1, 1976·Pharmakopsychiatrie, Neuro-Psychopharmakologie·M Lader
Aug 1, 1977·The British Journal of Psychiatry : the Journal of Mental Science·O T PhillipsonA F Healey
Oct 31, 1975·Psychopharmacologia·Y SakuraiR Takahashi

Related Concepts

Metabolic Process, Cellular
Drug Response
Antipsychotic Effect
Antipsychotic Agents
Metabolic Pathway
Radioligand Assay
Antispasmodic Effect
Bos indicus

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here