PMID: 6107947Jan 1, 1980Paper

Neuroleptic blood levels and therapeutic effect

Psychopharmacology
B M CohenR I Altesman

Abstract

Studies attempting to delineate a therapeutic range of blood levels for neuroleptics have yielded conflicting results. The reasons for this are briefly reviewed and a study is described in which a correlation is sought between blood levels of thioridazine and clinical efficacy. The study employs the radioreceptor assay for neuroleptics to detect both parent drug and active metabolites in blood. The results of the study indicate that while dose is a poor predictor of blood levels of medication, blood levels of neuroleptic activity in patients on thioridazine may be very highly correlated with antipsychotic effect.

References

Aug 1, 1977·Archives of General Psychiatry·R J Baldessarini, J E Fischer
Sep 1, 1978·Archives of General Psychiatry·P R May, T Van Putten
Jul 1, 1976·Pharmakopsychiatrie, Neuro-Psychopharmakologie·M Lader
Jan 1, 1976·International Review of Neurobiology·T B CooperJ H Lee
Jan 1, 1972·Archives of General Psychiatry·J P FeighnerR Munoz
May 1, 1980·Psychiatry Research·B M CohenM Friedman
Jul 1, 1980·Neuropharmacology·B M CohenR J Baldessarini

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Citations

Oct 1, 1984·Biulleten' eksperimental'noĭ biologii i meditsiny·M F Mineeva, K S Raevskiĭ
Jul 1, 1980·Neuropharmacology·B M CohenR J Baldessarini
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·J L SantosJ A Cabranes
Aug 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·M PeetR A Yates
Jun 1, 1984·The British Journal of Psychiatry : the Journal of Mental Science·R G McCreadieC Menzies
Feb 1, 1986·The British Journal of Psychiatry : the Journal of Mental Science·J KrskaS D Soni
May 1, 1988·Drug Intelligence & Clinical Pharmacy·J J SramekR Hahn

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