PMID: 6111766Apr 1, 1981Paper

Neuroleptic-induced acute dystonic reactions may be due to enhanced dopamine release on to supersensitive postsynaptic receptors

Neurology
H KolbeC D Marsden

Abstract

Oral administration of butaperazine (40 mg per kilogram) to rats increased dopamine turnover, as measured by elevation of striatal and mesolimbic concentrations of homovanillic acid and 3,4-dihydroxyphenylacetic acid, for 24 to 48 hours. Initially, this dose of butaperazine inhibited stereotyped behavior in response to subcutaneous administration of apomorphine, but this effect was reversed at 12 hours. Later, animals had normal or exaggerated responses to apomorphine. The data suggest that the critical 20- to 28-hour period after butaperazine administration, when most human acute dystonic reactions occur, normal or supersensitive cerebral dopamine receptors are exposed to an excessive synaptic release of dopamine. This may be responsible for the drug-induced dystonia.

Citations

Jan 1, 1989·Psychopharmacology·M Elphick
Jul 1, 1988·Journal of Neurology, Neurosurgery, and Psychiatry·C S Lu, N S Chu
Nov 1, 1984·Journal of Pharmaceutical Sciences·A M CriderS Fahn
Jan 4, 2006·Hormones and Behavior·Anita N DiMeo, Ruth I Wood
Dec 1, 1992·The Australian and New Zealand Journal of Psychiatry·P Sachdev, W M Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here