Neuroleptic-induced dementia documented in four adults with mental retardation

Mental Retardation
A Gedye

Abstract

This is the first report to my knowledge of neuroleptic-induced dementia in adults with mental retardation. Four adults showed full recovery after having significant cognitive deterioration that persisted until the offending medication was withdrawn. The ages at onset of dementia were 37, 37, 39, and 55 years; the duration of dementia ranged from .5 to 2.5 years. Three adults had Down syndrome and one had mental retardation due to an unknown cause. The neuroleptic-induced dementia occurred while the individuals were on a low dose of either loxapine, thioridazine, haloperidol, or pimozide.

Citations

Sep 8, 2010·European Eating Disorders Review : the Journal of the Eating Disorders Association·Ceri J Jones, Judith Samuel
Dec 27, 2005·Human Psychopharmacology·Giampaolo La MalfaAlessandro Castellani
Sep 8, 2020·Expert Opinion on Drug Safety·Felice IasevoliAndrea de Bartolomeis

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