PMID: 6538629Apr 9, 1984Paper

Neuroleptic-induced dopamine hyposensitivity

Life Sciences
C G GoetzH L Klawans

Abstract

In contrast to dopaminergic hypersensitivity induced by most neuroleptic drugs including fluphenazine, thioridazine induced hyposensitivity to subsequent apomorphine stereotypy in rats. The difference between thioridazine and fluphenazine may relate in part to anticholinergic properties of thioridazine, but appears to involve additional mechanisms. Differences in dopaminergic sensitization may be important to the management and prevention of tardive dyskinesia an iatrogenic disorder associated with chronic exposure to neuroleptics.

References

Jan 1, 1981·Neurology·M Kamin, D Biddle
Mar 1, 1981·Neurology·P A NausiedaH L Klawans
Jun 21, 1974·Science·S H SnyderD Greenberg

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Citations

Jan 1, 1987·Journal of Neural Transmission·J A GrebbW J Freed
Jan 21, 1986·European Journal of Pharmacology·P M CarveyH L Klawans
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·P M CarveyH L Klawans
Jan 1, 1989·Progress in Neuro-psychopharmacology & Biological Psychiatry·J HietalaM Röyttä

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